1rz7

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{{Seed}}
 
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[[Image:1rz7.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D==
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The line below this paragraph, containing "STRUCTURE_1rz7", creates the "Structure Box" on the page.
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<StructureSection load='1rz7' size='340' side='right'caption='[[1rz7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rz7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1rz7| PDB=1rz7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz7 OCA], [https://pdbe.org/1rz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz7 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz7 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rz7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
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===CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D===
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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267<ref>PMID:14981267</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1rz7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14981267}}, adds the Publication Abstract to the page
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*[[Antibody 3D structures|Antibody 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14981267 is the PubMed ID number.
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*[[Sandbox 20009|Sandbox 20009]]
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*[[3D structures of human antibody|3D structures of human antibody]]
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{{ABSTRACT_PUBMED_14981267}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ7 OCA].
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</StructureSection>
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[[Category: Homo sapiens]]
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==Reference==
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[[Category: Large Structures]]
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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981267 14981267]
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[[Category: Choe H]]
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[[Category: Choe, H.]]
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[[Category: Dimitrov DS]]
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[[Category: Dimitrov, D S.]]
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[[Category: Farzan M]]
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[[Category: Farzan, M.]]
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[[Category: Hendrickson WA]]
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[[Category: Hendrickson, W A.]]
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[[Category: Huang CC]]
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[[Category: Huang, C C.]]
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[[Category: Kwong PD]]
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[[Category: Kwong, P D.]]
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[[Category: Majeed S]]
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[[Category: Majeed, S.]]
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[[Category: Moore MJ]]
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[[Category: Moore, M J.]]
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[[Category: Phogat S]]
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[[Category: Phogat, S.]]
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[[Category: Robinson J]]
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[[Category: Robinson, J.]]
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[[Category: Sodroski J]]
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[[Category: Sodroski, J.]]
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[[Category: Venturi M]]
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[[Category: Venturi, M.]]
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[[Category: Wyatt R]]
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[[Category: Wyatt, R.]]
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[[Category: Zhang M-Y]]
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[[Category: Zhang, M Y.]]
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[[Category: Antibody]]
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[[Category: Cd4i]]
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[[Category: Gp120]]
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[[Category: Hiv-1]]
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[[Category: Tyrosine sulfation]]
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[[Category: Vh-gene usage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:18:20 2008''
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Current revision

CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D

PDB ID 1rz7

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