2ifs

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{{Seed}}
 
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[[Image:2ifs.png|left|200px]]
 
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==Structure of the N-WASP EVH1 domain in complex with an extended WIP peptide==
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The line below this paragraph, containing "STRUCTURE_2ifs", creates the "Structure Box" on the page.
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<StructureSection load='2ifs' size='340' side='right'caption='[[2ifs]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ifs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IFS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ifs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ifs OCA], [https://pdbe.org/2ifs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ifs RCSB], [https://www.ebi.ac.uk/pdbsum/2ifs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ifs ProSAT]</span></td></tr>
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{{STRUCTURE_2ifs| PDB=2ifs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WASL_RAT WASL_RAT] Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity).[UniProtKB:O00401][UniProtKB:Q91YD9]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2ifs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ifs ConSurf].
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<div style="clear:both"></div>
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===Structure of the N-WASP EVH1 domain in complex with an extended WIP peptide===
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==See Also==
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*[[Wiskott-Aldrich syndrome protein 3D structures|Wiskott-Aldrich syndrome protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17229736}}, adds the Publication Abstract to the page
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[[Category: Homo sapiens]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17229736 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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{{ABSTRACT_PUBMED_17229736}}
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[[Category: Deng Q]]
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[[Category: Peterson FC]]
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==About this Structure==
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[[Category: Volkman BF]]
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2IFS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_rattus_norvegicus Homo sapiens, rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFS OCA].
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==Reference==
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Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP., Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF, J Biol Chem. 2007 Mar 16;282(11):8446-53. Epub 2007 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17229736 17229736]
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[[Category: Homo sapiens, rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Deng, Q.]]
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[[Category: Peterson, F C.]]
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[[Category: Volkman, B F.]]
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[[Category: Nmr]]
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[[Category: Polyproline]]
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[[Category: Protein-protein complex]]
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[[Category: Verprolin]]
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[[Category: Wiskott-aldrich syndrome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:27:22 2008''
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Current revision

Structure of the N-WASP EVH1 domain in complex with an extended WIP peptide

PDB ID 2ifs

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