1r6k

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{{Seed}}
 
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[[Image:1r6k.png|left|200px]]
 
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==HPV11 E2 TAD crystal structure==
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The line below this paragraph, containing "STRUCTURE_1r6k", creates the "Structure Box" on the page.
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<StructureSection load='1r6k' size='340' side='right'caption='[[1r6k]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_11 Human papillomavirus 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R6K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6k OCA], [https://pdbe.org/1r6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r6k RCSB], [https://www.ebi.ac.uk/pdbsum/1r6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6k ProSAT]</span></td></tr>
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{{STRUCTURE_1r6k| PDB=1r6k | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VE2_HPV11 VE2_HPV11] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r6k ConSurf].
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<div style="clear:both"></div>
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===HPV11 E2 TAD crystal structure===
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14634007}}, adds the Publication Abstract to the page
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[[Category: Human papillomavirus 11]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14634007 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Coulombe R]]
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{{ABSTRACT_PUBMED_14634007}}
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[[Category: Wang Y]]
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==About this Structure==
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1R6K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_11 Human papillomavirus type 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6K OCA].
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==Reference==
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Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor., Wang Y, Coulombe R, Cameron DR, Thauvette L, Massariol MJ, Amon LM, Fink D, Titolo S, Welchner E, Yoakim C, Archambault J, White PW, J Biol Chem. 2004 Feb 20;279(8):6976-85. Epub 2003 Nov 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14634007 14634007]
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[[Category: Human papillomavirus type 11]]
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[[Category: Single protein]]
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[[Category: Coulombe, R.]]
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[[Category: Wang, Y.]]
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[[Category: E2 tad]]
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[[Category: Papillomavirus]]
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[[Category: Replication]]
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[[Category: Tad domain]]
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[[Category: Transcription]]
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[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:47:53 2008''
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Current revision

HPV11 E2 TAD crystal structure

PDB ID 1r6k

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