1wt2

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{{Seed}}
 
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[[Image:1wt2.png|left|200px]]
 
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==Mutant human ABO(H) blood group glycosyltransferase A with bound UDP and inhibitor==
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The line below this paragraph, containing "STRUCTURE_1wt2", creates the "Structure Box" on the page.
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<StructureSection load='1wt2' size='340' side='right'caption='[[1wt2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WT2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLG:HEXYL+3-DEOXY-BETA-D-GALACTOPYRANOSE'>DLG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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{{STRUCTURE_1wt2| PDB=1wt2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wt2 OCA], [https://pdbe.org/1wt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wt2 RCSB], [https://www.ebi.ac.uk/pdbsum/1wt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wt2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wt/1wt2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wt2 ConSurf].
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<div style="clear:both"></div>
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===Mutant human ABO(H) blood group glycosyltransferase A with bound UDP and inhibitor===
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==See Also==
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15475562}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15475562 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15475562}}
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==About this Structure==
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1WT2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT2 OCA].
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==Reference==
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Structural basis for the inactivity of human blood group O2 glycosyltransferase., Lee HJ, Barry CH, Borisova SN, Seto NO, Zheng RB, Blancher A, Evans SV, Palcic MM, J Biol Chem. 2005 Jan 7;280(1):525-9. Epub 2004 Oct 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15475562 15475562]
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[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Barry, C H.]]
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[[Category: Barry CH]]
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[[Category: Blancher, A.]]
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[[Category: Blancher A]]
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[[Category: Borisova, S N.]]
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[[Category: Borisova SN]]
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[[Category: Evans, S V.]]
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[[Category: Evans SV]]
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[[Category: Lee, H J.]]
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[[Category: Lee HJ]]
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[[Category: Palcic, M M.]]
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[[Category: Palcic MM]]
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[[Category: Seto, N O.L.]]
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[[Category: Seto NOL]]
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[[Category: Zheng, R B.]]
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[[Category: Zheng RB]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:49:29 2008''
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Current revision

Mutant human ABO(H) blood group glycosyltransferase A with bound UDP and inhibitor

PDB ID 1wt2

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