1pd3

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[[Image:1pd3.png|left|200px]]
 
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==Influenza A NEP M1-binding domain==
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The line below this paragraph, containing "STRUCTURE_1pd3", creates the "Structure Box" on the page.
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<StructureSection load='1pd3' size='340' side='right'caption='[[1pd3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PD3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pd3 OCA], [https://pdbe.org/1pd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pd3 RCSB], [https://www.ebi.ac.uk/pdbsum/1pd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pd3 ProSAT]</span></td></tr>
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{{STRUCTURE_1pd3| PDB=1pd3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEP_I34A1 NEP_I34A1] Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
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===Influenza A NEP M1-binding domain===
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==See Also==
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*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
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[[Category: Influenza A virus]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12970177 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Baudin F]]
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{{ABSTRACT_PUBMED_12970177}}
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==About this Structure==
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1PD3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PD3 OCA].
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==Reference==
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Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)., Akarsu H, Burmeister WP, Petosa C, Petit I, Muller CW, Ruigrok RW, Baudin F, EMBO J. 2003 Sep 15;22(18):4646-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12970177 12970177]
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[[Category: Influenza a virus]]
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[[Category: Single protein]]
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[[Category: Baudin, F.]]
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[[Category: Influenza virus some]]
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[[Category: Nep/ns2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:11 2008''
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Current revision

Influenza A NEP M1-binding domain

PDB ID 1pd3

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