1k4a

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{{Seed}}
 
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[[Image:1k4a.png|left|200px]]
 
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==STRUCTURE OF AGAA RNA TETRALOOP, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1k4a", creates the "Structure Box" on the page.
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<StructureSection load='1k4a' size='340' side='right'caption='[[1k4a]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k4a]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K4A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4a OCA], [https://pdbe.org/1k4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k4a RCSB], [https://www.ebi.ac.uk/pdbsum/1k4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k4a ProSAT]</span></td></tr>
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{{STRUCTURE_1k4a| PDB=1k4a | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RNases III are a family of double-stranded RNA (dsRNA) endoribonucleases involved in the processing and decay of a large number of cellular RNAs as well as in RNA interference. The dsRNA substrates of Saccharomyces cerevisiae RNase III (Rnt1p) are capped by tetraloops with the consensus sequence AGNN, which act as the primary docking site for the RNase. We have solved the solution structures of two RNA hairpins capped by AGNN tetraloops, AGAA and AGUU, using NMR spectroscopy. Both tetraloops have the same overall structure, in which the backbone turn occurs on the 3' side of the syn G residue in the loop, with the first A and G in a 5' stack and the last two residues in a 3' stack. A non-bridging phosphate oxygen and the universal G which are essential for Rnt1p binding are strongly exposed. The compared biochemical and structural analysis of various tetraloop sequences defines a novel family of RNA tetraloop fold with the consensus (U/A)GNN and implicates this conserved structure as the primary determinant for specific recognition of Rnt1p substrates.
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===STRUCTURE OF AGAA RNA TETRALOOP, NMR, 20 STRUCTURES===
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A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III.,Wu H, Yang PK, Butcher SE, Kang S, Chanfreau G, Feigon J EMBO J. 2001 Dec 17;20(24):7240-9. PMID:11743000<ref>PMID:11743000</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1k4a" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11743000 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11743000}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4A OCA].
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[[Category: Butcher SE]]
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[[Category: Chanfreau G]]
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==Reference==
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[[Category: Feigon J]]
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A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III., Wu H, Yang PK, Butcher SE, Kang S, Chanfreau G, Feigon J, EMBO J. 2001 Dec 17;20(24):7240-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11743000 11743000]
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[[Category: Kang S]]
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[[Category: Butcher, S E.]]
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[[Category: Wu H]]
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[[Category: Chanfreau, G.]]
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[[Category: Yang PK]]
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[[Category: Feigon, J.]]
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[[Category: Kang, S.]]
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[[Category: Wu, H.]]
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[[Category: Yang, P K.]]
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[[Category: Ribonucleic acid]]
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[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:10:38 2008''
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Current revision

STRUCTURE OF AGAA RNA TETRALOOP, NMR, 20 STRUCTURES

PDB ID 1k4a

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