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1pos

From Proteopedia

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{{Seed}}
 
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[[Image:1pos.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF A NOVEL DISULFIDE-LINKED "TREFOIL" MOTIF FOUND IN A LARGE FAMILY OF PUTATIVE GROWTH FACTORS==
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The line below this paragraph, containing "STRUCTURE_1pos", creates the "Structure Box" on the page.
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<StructureSection load='1pos' size='340' side='right'caption='[[1pos]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1POS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_1pos| PDB=1pos | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pos OCA], [https://pdbe.org/1pos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pos RCSB], [https://www.ebi.ac.uk/pdbsum/1pos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pos ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF A NOVEL DISULFIDE-LINKED "TREFOIL" MOTIF FOUND IN A LARGE FAMILY OF PUTATIVE GROWTH FACTORS===
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== Function ==
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[https://www.uniprot.org/uniprot/TFF2_PIG TFF2_PIG] Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_8302836}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 8302836 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/1pos_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_8302836}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1POS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pos ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors., De A, Brown DG, Gorman MA, Carr M, Sanderson MR, Freemont PS, Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1084-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8302836 8302836]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Brown, D.]]
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[[Category: Brown D]]
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[[Category: Carr, M.]]
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[[Category: Carr M]]
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[[Category: De, A.]]
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[[Category: De A]]
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[[Category: Freemont, P S.]]
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[[Category: Freemont PS]]
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[[Category: Gorman, M.]]
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[[Category: Gorman M]]
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[[Category: Sanderson, M R.]]
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[[Category: Sanderson MR]]
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[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:11:38 2008''
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Current revision

CRYSTAL STRUCTURE OF A NOVEL DISULFIDE-LINKED "TREFOIL" MOTIF FOUND IN A LARGE FAMILY OF PUTATIVE GROWTH FACTORS

PDB ID 1pos

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