2ai8

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{{Seed}}
 
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[[Image:2ai8.png|left|200px]]
 
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==E.coli Polypeptide Deformylase complexed with SB-485343==
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The line below this paragraph, containing "STRUCTURE_2ai8", creates the "Structure Box" on the page.
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<StructureSection load='2ai8' size='340' side='right'caption='[[2ai8]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ai8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AI8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SB7:[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL'>SB7</scene></td></tr>
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{{STRUCTURE_2ai8| PDB=2ai8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ai8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ai8 OCA], [https://pdbe.org/2ai8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ai8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ai8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ai8 ProSAT]</span></td></tr>
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</table>
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===E.coli Polypeptide Deformylase complexed with SB-485343===
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== Function ==
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[https://www.uniprot.org/uniprot/DEF_ECOLI DEF_ECOLI] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12538898}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12538898 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2ai8_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12538898}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2AI8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AI8 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ai8 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species., Smith KJ, Petit CM, Aubart K, Smyth M, McManus E, Jones J, Fosberry A, Lewis C, Lonetto M, Christensen SB, Protein Sci. 2003 Feb;12(2):349-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12538898 12538898]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Peptide deformylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Aubart K]]
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[[Category: Aubart, K.]]
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[[Category: Christensen SB]]
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[[Category: Christensen, S B.]]
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[[Category: Fosberry A]]
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[[Category: Fosberry, A.]]
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[[Category: Jones J]]
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[[Category: Jones, J.]]
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[[Category: Lewis C]]
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[[Category: Lewis, C.]]
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[[Category: Lonetto M]]
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[[Category: Lonetto, M.]]
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[[Category: McManus E]]
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[[Category: McManus, E.]]
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[[Category: Petit CM]]
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[[Category: Petit, C M.]]
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[[Category: Smith KJ]]
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[[Category: Smith, K J.]]
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[[Category: Smyth M]]
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[[Category: Smyth, M.]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:26:56 2008''
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Current revision

E.coli Polypeptide Deformylase complexed with SB-485343

PDB ID 2ai8

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