1zb1

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{{Seed}}
 
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[[Image:1zb1.png|left|200px]]
 
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==Structure basis for endosomal targeting by the Bro1 domain==
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The line below this paragraph, containing "STRUCTURE_1zb1", creates the "Structure Box" on the page.
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<StructureSection load='1zb1' size='340' side='right'caption='[[1zb1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZB1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zb1 OCA], [https://pdbe.org/1zb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1zb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zb1 ProSAT]</span></td></tr>
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{{STRUCTURE_1zb1| PDB=1zb1 | SCENE= }}
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</table>
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== Function ==
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===Structure basis for endosomal targeting by the Bro1 domain===
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[https://www.uniprot.org/uniprot/BRO1_YEAST BRO1_YEAST] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. Acts as an adapter that recruits the DOA4 deubiquitinase to the endosomes, leading to deubiquitination of cargo proteins prior to the lumenal sequestration. Its association to the endosomes depends on SNF7 and its dissociation requires VPS4. Interacts functionally with the Pkc1p-mitogen-activated protein kinase pathway.<ref>PMID:8649366</ref> <ref>PMID:11454748</ref> <ref>PMID:12062418</ref> <ref>PMID:12668726</ref> <ref>PMID:14523026</ref> <ref>PMID:15326198</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15935782 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zb/1zb1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15935782}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zb1 ConSurf].
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1ZB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZB1 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structural basis for endosomal targeting by the Bro1 domain., Kim J, Sitaraman S, Hierro A, Beach BM, Odorizzi G, Hurley JH, Dev Cell. 2005 Jun;8(6):937-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15935782 15935782]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Beach BM]]
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[[Category: Beach, B M.]]
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[[Category: Hierro A]]
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[[Category: Hierro, A.]]
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[[Category: Hurley JH]]
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[[Category: Hurley, J H.]]
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[[Category: Kim J]]
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[[Category: Kim, J.]]
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[[Category: Odorizzi G]]
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[[Category: Odorizzi, G.]]
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[[Category: Sitaraman S]]
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[[Category: Sitaraman, S.]]
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[[Category: Aip1]]
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[[Category: Bro1]]
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[[Category: Bro1 domain]]
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[[Category: Snf7]]
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[[Category: Trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:27:56 2008''
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Current revision

Structure basis for endosomal targeting by the Bro1 domain

PDB ID 1zb1

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