1t41

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{{Seed}}
 
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[[Image:1t41.png|left|200px]]
 
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==Crystal structure of human aldose reductase complexed with NADP and IDD552==
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The line below this paragraph, containing "STRUCTURE_1t41", creates the "Structure Box" on the page.
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<StructureSection load='1t41' size='340' side='right'caption='[[1t41]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T41 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ID5:[5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC+ACID'>ID5</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_1t41| PDB=1t41 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t41 OCA], [https://pdbe.org/1t41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t41 RCSB], [https://www.ebi.ac.uk/pdbsum/1t41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t41 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t41_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t41 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human aldose reductase complexed with NADP and IDD552===
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==See Also==
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15272156}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15272156 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15272156}}
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==About this Structure==
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1T41 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T41 OCA].
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==Reference==
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The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48., Ruiz F, Hazemann I, Mitschler A, Joachimiak A, Schneider T, Karplus M, Podjarny A, Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1347-54. Epub 2004, Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15272156 15272156]
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chevrier, B.]]
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[[Category: Chevrier B]]
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[[Category: Hazemann, I.]]
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[[Category: Hazemann I]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak A]]
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[[Category: Karplus, M.]]
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[[Category: Karplus M]]
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[[Category: Mitschler, A.]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A.]]
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[[Category: Podjarny A]]
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[[Category: Ruiz, F.]]
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[[Category: Ruiz F]]
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[[Category: Schneider, T.]]
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[[Category: Schneider T]]
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[[Category: Aldose reductase]]
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[[Category: Atomic resolution]]
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[[Category: Inhibitor binding]]
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[[Category: Ternary complex]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:35:10 2008''
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Current revision

Crystal structure of human aldose reductase complexed with NADP and IDD552

PDB ID 1t41

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OCA

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