1qzw

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{{Seed}}
 
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[[Image:1qzw.png|left|200px]]
 
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==Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication==
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The line below this paragraph, containing "STRUCTURE_1qzw", creates the "Structure Box" on the page.
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<StructureSection load='1qzw' size='340' side='right'caption='[[1qzw]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qzw]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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{{STRUCTURE_1qzw| PDB=1qzw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qzw OCA], [https://pdbe.org/1qzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qzw RCSB], [https://www.ebi.ac.uk/pdbsum/1qzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qzw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRP54_SACS2 SRP54_SACS2] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.[HAMAP-Rule:MF_00306]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qzw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qzw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Targeting of secretory and membrane proteins by the signal recognition particle (SRP) is evolutionarily conserved, and the multidomain protein SRP54 acts as the key player in SRP-mediated protein transport. Binding of a signal peptide to SRP54 at the ribosome is coordinated with GTP binding and subsequent complex formation with the SRP receptor. Because these functions are localized to distinct domains of SRP54, communication between them is essential. We report the crystal structures of SRP54 from the Archaeon Sulfolobus solfataricus with and without its cognate SRP RNA binding site (helix 8) at 4-A resolution. The two structures show the flexibility of the SRP core and the position of SRP54 relative to the RNA. A long linker helix connects the GTPase (G domain) with the signal peptide binding (M) domain, and a hydrophobic contact between the N and M domains relates the signal peptide binding site to the G domain. Hinge regions are identified in the linker between the G and M domains (292-LGMGD) and in the N-terminal part of the M domain, which allow for structural rearrangements within SRP54 upon signal peptide binding at the ribosome.
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===Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication===
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Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication.,Rosendal KR, Wild K, Montoya G, Sinning I Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14701-6. Epub 2003 Dec 1. PMID:14657338<ref>PMID:14657338</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1qzw" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14657338}}, adds the Publication Abstract to the page
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*[[Signal recognition particle protein|Signal recognition particle protein]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14657338 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14657338}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1QZW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZW OCA].
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[[Category: Saccharolobus solfataricus]]
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[[Category: Montoya G]]
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==Reference==
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[[Category: Rosendal KR]]
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Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication., Rosendal KR, Wild K, Montoya G, Sinning I, Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14701-6. Epub 2003 Dec 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14657338 14657338]
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[[Category: Sinning I]]
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[[Category: Single protein]]
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[[Category: Wild K]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Montoya, G.]]
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[[Category: Rosendal, K R.]]
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[[Category: Sinning, I.]]
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[[Category: Wild, K.]]
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[[Category: Protein targeting]]
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[[Category: Protein-rna complex]]
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[[Category: Ribonucleoprotein complex]]
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[[Category: Signal recognition particle]]
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[[Category: Srp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:37:41 2008''
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Current revision

Crystal structure of the complete core of archaeal SRP and implications for inter-domain communication

PDB ID 1qzw

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