2pei

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{{Seed}}
 
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[[Image:2pei.png|left|200px]]
 
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==Crystal structure of selenomethionine-labeled RbcX==
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The line below this paragraph, containing "STRUCTURE_2pei", creates the "Structure Box" on the page.
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<StructureSection load='2pei' size='340' side='right'caption='[[2pei]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2pei]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Agmenellum_quadruplicatum Agmenellum quadruplicatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PEI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pej|2pej]], [[2pek|2pek]], [[2pem|2pem]], [[2pen|2pen]], [[2peo|2peo]], [[2peq|2peq]]</div></td></tr>
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{{STRUCTURE_2pei| PDB=2pei | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RbcX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32049 Agmenellum quadruplicatum])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pei OCA], [https://pdbe.org/2pei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pei RCSB], [https://www.ebi.ac.uk/pdbsum/2pei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pei ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2pei_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pei ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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After folding, many proteins must assemble into oligomeric complexes to become biologically active. Here we describe the role of RbcX as an assembly chaperone of ribulose-bisphosphate carboxylase/oxygenase (Rubisco), the enzyme responsible for the fixation of atmospheric carbon dioxide. In cyanobacteria and plants, Rubisco is an approximately 520 kDa complex composed of eight large subunits (RbcL) and eight small subunits (RbcS). We found that cyanobacterial RbcX functions downstream of chaperonin-mediated RbcL folding in promoting the formation of RbcL(8) core complexes. Structural analysis revealed that the 15 kDa RbcX forms a homodimer with two cooperating RbcL-binding regions. A central cleft specifically binds the exposed C-terminal peptide of RbcL subunits, enabling a peripheral surface of RbcX to mediate RbcL(8) assembly. Due to the dynamic nature of these interactions, RbcX is readily displaced from RbcL(8) complexes by RbcS, producing the active enzyme. The strategies employed by RbcX in achieving substrate specificity and efficient product release may be generally relevant in assisted assembly reactions.
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===Crystal structure of selenomethionine-labeled RbcX===
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Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco.,Saschenbrecker S, Bracher A, Rao KV, Rao BV, Hartl FU, Hayer-Hartl M Cell. 2007 Jun 15;129(6):1189-200. PMID:17574029<ref>PMID:17574029</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17574029}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2pei" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17574029 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17574029}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Agmenellum quadruplicatum]]
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2PEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp._pcc_7002 Synechococcus sp. pcc 7002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PEI OCA].
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[[Category: Large Structures]]
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[[Category: Bracher, A]]
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==Reference==
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[[Category: Hartl, F U]]
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Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco., Saschenbrecker S, Bracher A, Rao KV, Rao BV, Hartl FU, Hayer-Hartl M, Cell. 2007 Jun 15;129(6):1189-200. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17574029 17574029]
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[[Category: Hayer-Hartl, M]]
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[[Category: Single protein]]
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[[Category: Rao, B Vasudeva]]
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[[Category: Synechococcus sp. pcc 7002]]
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[[Category: Rao, K Vasudeva]]
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[[Category: Bracher, A.]]
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[[Category: Saschenbrecker, S]]
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[[Category: Hartl, F U.]]
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[[Category: Hayer-Hartl, M.]]
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[[Category: Rao, B Vasudeva.]]
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[[Category: Rao, K Vasudeva.]]
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[[Category: Saschenbrecker, S.]]
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[[Category: Chaperone]]
[[Category: Chaperone]]
[[Category: Helix bundle]]
[[Category: Helix bundle]]
[[Category: Protein complex assembly]]
[[Category: Protein complex assembly]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:05:58 2008''
 

Current revision

Crystal structure of selenomethionine-labeled RbcX

PDB ID 2pei

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