2viz

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{{Seed}}
 
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[[Image:2viz.png|left|200px]]
 
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==Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(2-oxo- 1-pyrrolidinyl)-5-(propyloxy)benzamide==
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The line below this paragraph, containing "STRUCTURE_2viz", creates the "Structure Box" on the page.
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<StructureSection load='2viz' size='340' side='right'caption='[[2viz]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2viz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VIZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VG4:N-[(1S,2R)-1-BENZYL-3-{[(1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL]AMINO}-2-HYDROXYPROPYL]-3-(2-OXO-2,3-DIHYDRO-1H-PYRROL-1-YL)-5-PROPOXYBENZAMIDE'>VG4</scene></td></tr>
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{{STRUCTURE_2viz| PDB=2viz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2viz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2viz OCA], [https://pdbe.org/2viz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2viz RCSB], [https://www.ebi.ac.uk/pdbsum/2viz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2viz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2viz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2viz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Inhibition of the aspartyl protease BACE-1 has the potential to deliver a disease-modifying therapy for Alzheimer's disease. Herein, is described the lead generation effort which resulted, with the support of X-ray crystallography, in the discovery of potent inhibitors based on a hydroxy ethylamine (HEA) transition-state mimetic. These inhibitors were capable of lowering amyloid production in a cell-based assay.
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===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(2-OXO-1-PYRROLIDINYL)-5-(PROPYLOXY) BENZAMIDE===
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BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).,Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G Bioorg Med Chem Lett. 2008 Feb 1;18(3):1011-6. Epub 2007 Dec 15. PMID:18171614<ref>PMID:18171614</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2viz" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18171614}}, adds the Publication Abstract to the page
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18171614 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18171614}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2VIZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIZ OCA].
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==Reference==
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BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs)., Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1011-6. Epub 2007 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18171614 18171614]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Clarke B]]
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[[Category: Brien, A O.]]
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[[Category: Demont E]]
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[[Category: Clarke, B.]]
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[[Category: Dingwall C]]
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[[Category: Demont, E.]]
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[[Category: Dunsdon R]]
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[[Category: Dingwall, C.]]
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[[Category: Faller A]]
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[[Category: Dunsdon, R.]]
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[[Category: Hawkins J]]
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[[Category: Faller, A.]]
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[[Category: Hussain I]]
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[[Category: Hawkins, J.]]
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[[Category: MacPherson D]]
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[[Category: Hussain, I.]]
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[[Category: Maile G]]
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[[Category: Macpherson, D.]]
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[[Category: Matico R]]
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[[Category: Maile, G.]]
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[[Category: Milner P]]
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[[Category: Matico, R.]]
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[[Category: Mosley J]]
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[[Category: Milner, P.]]
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[[Category: Naylor A]]
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[[Category: Mosley, J.]]
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[[Category: O'Brien A]]
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[[Category: Naylor, A.]]
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[[Category: Redshaw S]]
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[[Category: Redshaw, S.]]
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[[Category: Riddell D]]
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[[Category: Riddell, D.]]
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[[Category: Rowland P]]
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[[Category: Rowland, P.]]
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[[Category: Smith K]]
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[[Category: Smith, K.]]
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[[Category: Soleil V]]
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[[Category: Soleil, V.]]
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[[Category: Stanway S]]
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[[Category: Stanway, S.]]
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[[Category: Stemp G]]
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[[Category: Stemp, G.]]
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[[Category: Sweitzer S]]
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[[Category: Sweitzer, S.]]
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[[Category: Theobald P]]
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[[Category: Theobald, P.]]
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[[Category: Vesey D]]
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[[Category: Vesey, D.]]
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[[Category: Walter DS]]
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[[Category: Walter, D S.]]
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[[Category: Ward J]]
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[[Category: Ward, J.]]
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[[Category: Wayne G]]
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[[Category: Wayne, G.]]
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[[Category: Alternative splicing]]
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[[Category: Asp-2]]
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[[Category: Aspartyl protease]]
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[[Category: Bace-1]]
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[[Category: Beta-secretase]]
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[[Category: Beta-site app cleaving enzyme]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Memapsin-2]]
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[[Category: Membrane]]
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[[Category: Protease]]
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:11:48 2008''
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Current revision

Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(2-oxo- 1-pyrrolidinyl)-5-(propyloxy)benzamide

PDB ID 2viz

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