2auj

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{{Seed}}
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==Structure of Thermus aquaticus RNA polymerase beta'-subunit insert==
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[[Image:2auj.png|left|200px]]
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<StructureSection load='2auj' size='340' side='right' caption='[[2auj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2auj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUJ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2auk|2auk]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rpoC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auj OCA], [http://pdbe.org/2auj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2auj RCSB], [http://www.ebi.ac.uk/pdbsum/2auj PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2auj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The large beta and beta' subunits of the bacterial core RNA polymerase (RNAP) are highly conserved throughout evolution. Nevertheless, large sequence insertions in beta and beta' characterize specific evolutionary lineages of bacteria. The Thermus aquaticus RNAP beta' subunit contains a 283 residue insert between conserved regions A and B that is found in only four bacterial species. The Escherichia coli RNAP beta' subunit contains a 188 residue insert in the middle of conserved region G that is found in a wide range of bacterial species. Here, we present structural studies of these two beta' insertions. We show that the inserts comprise repeats of a previously characterized fold, the sandwich-barrel hybrid motif (as predicted from previous sequence analysis) and that the inserts serve significant roles in facilitating protein/protein and/or protein/nucleic acid interactions.
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Structure and function of lineage-specific sequence insertions in the bacterial RNA polymerase beta' subunit.,Chlenov M, Masuda S, Murakami KS, Nikiforov V, Darst SA, Mustaev A J Mol Biol. 2005 Oct 14;353(1):138-54. PMID:16154587<ref>PMID:16154587</ref>
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The line below this paragraph, containing "STRUCTURE_2auj", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2auj| PDB=2auj | SCENE= }}
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===Structure of Thermus aquaticus RNA polymerase beta'-subunit insert===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2auj" style="background-color:#fffaf0;"></div>
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==See Also==
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<!--
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*[[RNA polymerase|RNA polymerase]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16154587}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 16154587 is the PubMed ID number.
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<references/>
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-->
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__TOC__
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{{ABSTRACT_PUBMED_16154587}}
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</StructureSection>
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[[Category: Atcc 25104]]
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==About this Structure==
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2AUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUJ OCA].
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==Reference==
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Structure and function of lineage-specific sequence insertions in the bacterial RNA polymerase beta' subunit., Chlenov M, Masuda S, Murakami KS, Nikiforov V, Darst SA, Mustaev A, J Mol Biol. 2005 Oct 14;353(1):138-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16154587 16154587]
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[[Category: DNA-directed RNA polymerase]]
[[Category: DNA-directed RNA polymerase]]
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[[Category: Single protein]]
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[[Category: Chlenov, M]]
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[[Category: Thermus aquaticus]]
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[[Category: Darst, S A]]
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[[Category: Chlenov, M.]]
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[[Category: Masuda, S]]
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[[Category: Darst, S A.]]
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[[Category: Murakami, K S]]
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[[Category: Masuda, S.]]
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[[Category: Mustaev, A]]
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[[Category: Murakami, K S.]]
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[[Category: Nikiforov, V]]
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[[Category: Mustaev, A.]]
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[[Category: Nikiforov, V.]]
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[[Category: Sandwich-barrel hybrid motif]]
[[Category: Sandwich-barrel hybrid motif]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:17:44 2008''
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Current revision

Structure of Thermus aquaticus RNA polymerase beta'-subunit insert

2auj, resolution 2.70Å

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