2gfr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:13, 17 October 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2gfr.png|left|200px]]
 
-
<!--
+
==Solution structure of Amphibian tachykinin Uperolein bound to DPC micelles==
-
The line below this paragraph, containing "STRUCTURE_2gfr", creates the "Structure Box" on the page.
+
<StructureSection load='2gfr' size='340' side='right'caption='[[2gfr]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2gfr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Uperoleia_rugosa Uperoleia rugosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GFR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-
{{STRUCTURE_2gfr| PDB=2gfr | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gfr OCA], [https://pdbe.org/2gfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gfr RCSB], [https://www.ebi.ac.uk/pdbsum/2gfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gfr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TKN1_UPERU TKN1_UPERU] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Uperolein, a physalaemin-like endecapeptide, has been shown to be selective for Neurokinin 1 receptor. As a first step towards understanding the structure-activity relationship, we report the membrane-induced structure of Uperolein with the aid of circular dichroism and 2D (1)H NMR spectroscopy. Sequence-specific resonance assignments of protons have been made using correlation spectroscopy (TOCSY, DQF-COSY) and NOESY spectroscopy. The interproton distance constraints and dihedral angle constraints have been utilized to generate a family of structures using torsion angle molecular dynamics within program DYANA. The conformational range of the peptide revealed by NMR and CD studies has been analysed in terms of characteristic secondary features. Analysis of NMR data indicates that the global fold of Uperolein can be explained in terms of equilibrium between 3(10)-helix and alpha-helix from residues 5 to 11. An extended highly flexible N-terminus displays some degree of order and a possible turn structure. A comparison between the structures of Uperolein and Substance P, a prototype and endogenous Neurokinin 1 receptor agonist, indicates several common features in the distribution of hydrophobic and hydrophilic residues. Both the peptides show an amphiphilic character towards the middle region. The similarities suggest that the molecules interact with the receptor in an analogous manner.
-
===Solution structure of Amphibian tachykinin Uperolein bound to DPC micelles===
+
Solution structure of amphibian tachykinin Uperolein bound to DPC micelles.,Dike A, Cowsik SM J Struct Biol. 2006 Dec;156(3):442-52. Epub 2006 Aug 1. PMID:16979908<ref>PMID:16979908</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16979908}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2gfr" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16979908 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16979908}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2GFR is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFR OCA].
+
[[Category: Uperoleia rugosa]]
-
 
+
[[Category: Cowsik SM]]
-
==Reference==
+
[[Category: Dike A]]
-
Solution structure of amphibian tachykinin Uperolein bound to DPC micelles., Dike A, Cowsik SM, J Struct Biol. 2006 Dec;156(3):442-52. Epub 2006 Aug 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16979908 16979908]
+
-
[[Category: Single protein]]
+
-
[[Category: Cowsik, S M.]]
+
-
[[Category: Dike, A]]
+
-
[[Category: 3-10 helix]]
+
-
[[Category: Dpc micelle]]
+
-
[[Category: Helix]]
+
-
[[Category: Lipid induced conformation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:27:02 2008''
+

Current revision

Solution structure of Amphibian tachykinin Uperolein bound to DPC micelles

PDB ID 2gfr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gfr"
Personal tools