2byn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:49, 21 November 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2byn.png|left|200px]]
 
-
<!--
+
==Crystal structure of apo AChBP from Aplysia californica==
-
The line below this paragraph, containing "STRUCTURE_2byn", creates the "Structure Box" on the page.
+
<StructureSection load='2byn' size='340' side='right'caption='[[2byn]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2byn]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BYN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-
{{STRUCTURE_2byn| PDB=2byn | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2byn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2byn OCA], [https://pdbe.org/2byn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2byn RCSB], [https://www.ebi.ac.uk/pdbsum/2byn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2byn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/2byn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2byn ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Upon ligand binding at the subunit interfaces, the extracellular domain of the nicotinic acetylcholine receptor undergoes conformational changes, and agonist binding allosterically triggers opening of the ion channel. The soluble acetylcholine-binding protein (AChBP) from snail has been shown to be a structural and functional surrogate of the ligand-binding domain (LBD) of the receptor. Yet, individual AChBP species display disparate affinities for nicotinic ligands. The crystal structure of AChBP from Aplysia californica in the apo form reveals a more open loop C and distinctive positions for other surface loops, compared with previous structures. Analysis of Aplysia AChBP complexes with nicotinic ligands shows that loop C, which does not significantly change conformation upon binding of the antagonist, methyllycaconitine, further opens to accommodate the peptidic antagonist, alpha-conotoxin ImI, but wraps around the agonists lobeline and epibatidine. The structures also reveal extended and nonoverlapping interaction surfaces for the two antagonists, outside the binding loci for agonists. This comprehensive set of structures reflects a dynamic template for delineating further conformational changes of the LBD of the nicotinic receptor.
-
===CRYSTAL STRUCTURE OF APO ACHBP FROM APLYSIA CALIFORNICA===
+
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.,Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y EMBO J. 2005 Oct 19;24(20):3635-46. Epub 2005 Sep 29. PMID:16193063<ref>PMID:16193063</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2byn" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16193063}}, adds the Publication Abstract to the page
+
*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16193063 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16193063}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2BYN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYN OCA].
+
-
 
+
-
==Reference==
+
-
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations., Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y, EMBO J. 2005 Oct 19;24(20):3635-46. Epub 2005 Sep 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16193063 16193063]
+
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Bourne, Y.]]
+
[[Category: Bourne Y]]
-
[[Category: Hansen, S B.]]
+
[[Category: Hansen SB]]
-
[[Category: Huxford, T.]]
+
[[Category: Huxford T]]
-
[[Category: Marchot, P.]]
+
[[Category: Marchot P]]
-
[[Category: Sulzenbacher, G.]]
+
[[Category: Sulzenbacher G]]
-
[[Category: Taylor, P.]]
+
[[Category: Taylor P]]
-
[[Category: Acetylcholine binding protein]]
+
-
[[Category: Conformational flexibility]]
+
-
[[Category: Nicotinic acetylcholine receptor]]
+
-
[[Category: Soluble acetylcholine receptor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:33:41 2008''
+

Current revision

Crystal structure of apo AChBP from Aplysia californica

PDB ID 2byn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2byn"
Personal tools