2be1

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{{Seed}}
 
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[[Image:2be1.png|left|200px]]
 
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==Structure of the compact lumenal domain of yeast Ire1==
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The line below this paragraph, containing "STRUCTURE_2be1", creates the "Structure Box" on the page.
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<StructureSection load='2be1' size='340' side='right'caption='[[2be1]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2be1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BE1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.983&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2be1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2be1 OCA], [https://pdbe.org/2be1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2be1 RCSB], [https://www.ebi.ac.uk/pdbsum/2be1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2be1 ProSAT]</span></td></tr>
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{{STRUCTURE_2be1| PDB=2be1 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IRE1_YEAST IRE1_YEAST] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.<ref>PMID:8663458</ref> <ref>PMID:8670804</ref> <ref>PMID:9323131</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2be1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2be1 ConSurf].
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<div style="clear:both"></div>
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===Structure of the compact lumenal domain of yeast Ire1===
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==See Also==
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*[[Ire1|Ire1]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16365312}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16365312 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_16365312}}
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==About this Structure==
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2BE1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BE1 OCA].
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==Reference==
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On the mechanism of sensing unfolded protein in the endoplasmic reticulum., Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P, Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773-84. Epub 2005 Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16365312 16365312]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Credle JJ]]
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[[Category: Credle, J J.]]
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[[Category: Finer-Moore JS]]
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[[Category: Finer-Moore, J S.]]
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[[Category: Papa FR]]
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[[Category: Papa, F R.]]
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[[Category: Stroud RM]]
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[[Category: Stroud, R M.]]
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[[Category: Walter P]]
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[[Category: Walter, P.]]
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[[Category: Peptide-binding groove peptide-mediated oligomerization beta-propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:35:39 2008''
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Current revision

Structure of the compact lumenal domain of yeast Ire1

PDB ID 2be1

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