1noq

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{{Seed}}
 
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[[Image:1noq.png|left|200px]]
 
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==e-motif structure==
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The line below this paragraph, containing "STRUCTURE_1noq", creates the "Structure Box" on the page.
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<StructureSection load='1noq' size='340' side='right'caption='[[1noq]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1noq]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NOQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1noq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1noq OCA], [https://pdbe.org/1noq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1noq RCSB], [https://www.ebi.ac.uk/pdbsum/1noq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1noq ProSAT]</span></td></tr>
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{{STRUCTURE_1noq| PDB=1noq | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Recent molecular genetics studies have revealed a correlation between spontaneous, progressive expansion of several DNA trinucleotide repeats and certain hereditary neurodegenerative diseases. Triplet repeat (TR) sequences may be present in structured forms that can mediate the processes interrupting normal cellular replication, transcription, or repair activities, eventually leading to gene mutation. Using high resolution NMR spectroscopy and other biophysical methods, we probed the solution structures and properties of single-stranded TR sequences. These studies have led to the discovery of a new duplex motif (e-motif), present in CCG repeats, and to the elucidation of the structure of the (CTG)3 duplex. In this paper we provide a global picture of the solution behavior of the human disease-related CXG (X = A, C, G, or T) and the comparison GXC (X = A, or T) TR sequences. All six triplet repeats form antiparallel duplexes. The mismatched bases in CAG and CGG repeat duplexes are rather flexible and they do not appear to form stable, paired conformations. By comparison, GAC repeat duplexes and their mismatched A residues are well-structured. Most interestingly, the structures of the disease-related CXG repeats exhibit a propensity for folding at chain lengths as short as 12 residues. Furthermore, the energy barrier for the formation of homo-duplexes from the corresponding complementary hetero-duplexes are much lower for the CXG TR sequences than for the GAC or GTC TR sequences. These results provide insights into the conformation and physiochemical properties of TR sequences. Thus, a basis is provided for further studies of the behavior of long TR sequences in an effort to elucidate the molecular mechanisms of in vivo expansion and function of TR sequences.
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===e-motif structure===
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Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study.,Zheng M, Huang X, Smith GK, Yang X, Gao X J Mol Biol. 1996 Nov 29;264(2):323-36. PMID:8951379<ref>PMID:8951379</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_8951379}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1noq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 8951379 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8951379}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOQ OCA].
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[[Category: Gao X]]
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[[Category: Huang X]]
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==Reference==
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[[Category: Smith GK]]
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Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study., Zheng M, Huang X, Smith GK, Yang X, Gao X, J Mol Biol. 1996 Nov 29;264(2):323-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8951379 8951379]
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[[Category: Yang X]]
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[[Category: Gao, X.]]
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[[Category: Zheng M]]
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[[Category: Huang, X.]]
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[[Category: Smith, G K.]]
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[[Category: Yang, X.]]
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[[Category: Zheng, M.]]
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[[Category: E-motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:54:31 2008''
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Current revision

e-motif structure

PDB ID 1noq

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