1t3q

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{{Seed}}
 
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[[Image:1t3q.png|left|200px]]
 
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==Crystal structure of quinoline 2-Oxidoreductase from Pseudomonas Putida 86==
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The line below this paragraph, containing "STRUCTURE_1t3q", creates the "Structure Box" on the page.
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<StructureSection load='1t3q' size='340' side='right'caption='[[1t3q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t3q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MCN:PTERIN+CYTOSINE+DINUCLEOTIDE'>MCN</scene>, <scene name='pdbligand=SMO:DIOXOSULFIDOMOLYBDENUM(VI)+ION'>SMO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1t3q| PDB=1t3q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3q OCA], [https://pdbe.org/1t3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3q RCSB], [https://www.ebi.ac.uk/pdbsum/1t3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P72223_PSEPU P72223_PSEPU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The soil bacterium Pseudomonas putida 86 uses quinoline as a sole source of carbon and energy. Quinoline 2-oxidoreductase (Qor) catalyzes the first metabolic step converting quinoline to 2-oxo-1,2-dihydroquinoline. Qor is a member of the molybdenum hydroxylases. The molybdenum ion is coordinated by two ene-dithiolate sulfur atoms, two oxo-ligands, and a catalytically crucial sulfido-ligand, whose position in the active site was controversial. The 1.8 A resolution crystal structure of Qor indicates that the sulfido-ligand occupies the equatorial position at the molybdenum ion. The structural comparison of Qor with the allopurinol-inhibited xanthine dehydrogenase from Rhodobacter capsulatus allows direct insight into the mechanism of substrate recognition and the identification of putative catalytic residues. The active site protein variants QorE743V and QorE743D were analyzed to assess the catalytic role of E743.
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===Crystal structure of quinoline 2-Oxidoreductase from Pseudomonas Putida 86===
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Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase.,Bonin I, Martins BM, Purvanov V, Fetzner S, Huber R, Dobbek H Structure. 2004 Aug;12(8):1425-35. PMID:15296736<ref>PMID:15296736</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_15296736}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1t3q" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15296736 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15296736}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1T3Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3Q OCA].
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==Reference==
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Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase., Bonin I, Martins BM, Purvanov V, Fetzner S, Huber R, Dobbek H, Structure. 2004 Aug;12(8):1425-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15296736 15296736]
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[[Category: Protein complex]]
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[[Category: Pseudomonas putida]]
[[Category: Pseudomonas putida]]
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[[Category: Quinoline 2-oxidoreductase]]
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[[Category: Bonin I]]
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[[Category: Bonin, I.]]
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[[Category: Dobbek H]]
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[[Category: Dobbek, H.]]
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[[Category: Fetzner S]]
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[[Category: Fetzner, S.]]
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[[Category: Huber R]]
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[[Category: Huber, R.]]
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[[Category: Martins BM]]
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[[Category: Martins, B M.]]
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[[Category: Purvanov V]]
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[[Category: Purvanov, V.]]
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[[Category: Mcd]]
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[[Category: Molybdenum]]
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[[Category: Qor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:55:23 2008''
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Current revision

Crystal structure of quinoline 2-Oxidoreductase from Pseudomonas Putida 86

PDB ID 1t3q

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