2c3e

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{{Seed}}
 
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[[Image:2c3e.png|left|200px]]
 
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==The bovine mitochondrial ADP-ATP carrier==
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The line below this paragraph, containing "STRUCTURE_2c3e", creates the "Structure Box" on the page.
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<StructureSection load='2c3e' size='340' side='right'caption='[[2c3e]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2c3e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C3E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CXT:CARBOXYATRACTYLOSIDE'>CXT</scene></td></tr>
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{{STRUCTURE_2c3e| PDB=2c3e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3e OCA], [https://pdbe.org/2c3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c3e RCSB], [https://www.ebi.ac.uk/pdbsum/2c3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c3e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADT1_BOVIN ADT1_BOVIN] Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/2c3e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c3e ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The oligomerization state of the ADP/ATP carrier is an important issue in understanding the mechanism underlying nucleotide exchange across the inner mitochondrial membrane. The first high resolution structure obtained in the presence of carboxyatractyloside revealed a large cavity formed within a monomer in which the inhibitor is strongly bound. Whereas the protein-protein interactions implicated in the first crystal form are not biologically relevant, the new crystal form described herein, highlights favorable protein-protein interactions. The interactions are mediated by endogenous cardiolipins, which are tightly bound to the protein, two cardiolipins being sandwiched between the monomers on the matrix side. The putative dimerization interface evidenced here is consistent with other structural, biochemical or functional data published so far.
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===THE BOVINE MITOCHONDRIAL ADP-ATP CARRIER===
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Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomers.,Nury H, Dahout-Gonzalez C, Trezeguet V, Lauquin G, Brandolin G, Pebay-Peyroula E FEBS Lett. 2005 Nov 7;579(27):6031-6. Epub 2005 Oct 6. PMID:16226253<ref>PMID:16226253</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16226253}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2c3e" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16226253 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16226253}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2C3E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3E OCA].
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==Reference==
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Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomers., Nury H, Dahout-Gonzalez C, Trezeguet V, Lauquin G, Brandolin G, Pebay-Peyroula E, FEBS Lett. 2005 Nov 7;579(27):6031-6. Epub 2005 Oct 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16226253 16226253]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brandolin, G.]]
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[[Category: Brandolin G]]
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[[Category: Dahout-Gonzalez, C.]]
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[[Category: Dahout-Gonzalez C]]
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[[Category: Lauquin, G.]]
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[[Category: Lauquin G]]
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[[Category: Nury, H.]]
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[[Category: Nury H]]
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[[Category: Pebay-Peyroula, E.]]
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[[Category: Pebay-Peyroula E]]
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[[Category: Trezeguet, V.]]
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[[Category: Trezeguet V]]
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[[Category: Membrane protein]]
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[[Category: Mitochondrial carrier]]
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[[Category: Nucleotide transport]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:00:33 2008''
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Current revision

The bovine mitochondrial ADP-ATP carrier

PDB ID 2c3e

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