2ovh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:53, 13 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2ovh.png|left|200px]]
 
-
<!--
+
==Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT==
-
The line below this paragraph, containing "STRUCTURE_2ovh", creates the "Structure Box" on the page.
+
<StructureSection load='2ovh' size='340' side='right'caption='[[2ovh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2ovh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AS0:4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE+OXIME'>AS0</scene></td></tr>
-
{{STRUCTURE_2ovh| PDB=2ovh | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovh OCA], [https://pdbe.org/2ovh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovh RCSB], [https://www.ebi.ac.uk/pdbsum/2ovh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/2ovh_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ovh ConSurf].
 +
<div style="clear:both"></div>
-
===Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT===
+
==See Also==
-
 
+
*[[Progesterone receptor|Progesterone receptor]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17356170}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 17356170 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_17356170}}
+
-
 
+
-
==About this Structure==
+
-
2OVH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVH OCA].
+
-
 
+
-
==Reference==
+
-
A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator., Madauss KP, Grygielko ET, Deng SJ, Sulpizio AC, Stanley TB, Wu C, Short SA, Thompson SK, Stewart EL, Laping NJ, Williams SP, Bray JD, Mol Endocrinol. 2007 May;21(5):1066-81. Epub 2007 Mar 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17356170 17356170]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Deng, S J.]]
+
[[Category: Deng S-J]]
-
[[Category: Madauss, K P.]]
+
[[Category: Madauss KP]]
-
[[Category: Short, S A.]]
+
[[Category: Short SA]]
-
[[Category: Stewart, E L.]]
+
[[Category: Stewart EL]]
-
[[Category: Williams, S P.]]
+
[[Category: Williams SP]]
-
[[Category: Asoprisnil]]
+
-
[[Category: Co-repressor]]
+
-
[[Category: Nuclear receptor]]
+
-
[[Category: Pr]]
+
-
[[Category: Progesterone receptor]]
+
-
[[Category: Steroid receptor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:13:39 2008''
+

Current revision

Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor SMRT

PDB ID 2ovh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ovh"
Personal tools