2hxw

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{{Seed}}
 
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[[Image:2hxw.png|left|200px]]
 
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==Crystal Structure of Peb3 from Campylobacter jejuni==
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The line below this paragraph, containing "STRUCTURE_2hxw", creates the "Structure Box" on the page.
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<StructureSection load='2hxw' size='340' side='right'caption='[[2hxw]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hxw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HXW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2hxw| PDB=2hxw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxw OCA], [https://pdbe.org/2hxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hxw RCSB], [https://www.ebi.ac.uk/pdbsum/2hxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hxw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0PBL7_CAMJE Q0PBL7_CAMJE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/2hxw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hxw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Campylobacter jejuni is unusual among bacteria in possessing a eukaryotic-like system for N-linked protein glycosylation at Asn residues in sequons of the type Asp/Glu-Xaa-Asn-Xaa-Ser/Thr. However, little is known about the structural context of the glycosylated sequons, limiting the design of novel recombinant glycoproteins. To obtain more information on sequon structure, we have determined the crystal structure of the PEB3 (Cj0289c) dimer. PEB3 has the class II periplasmic-binding protein fold, with each monomer having two domains with a ligand-binding site containing citrate located between them, and overall resembles molybdate- and sulfate-binding proteins. The sequon around Asn90 is located within a surface-exposed loop joining two structural elements. The three key residues are well exposed on the surface; hence, they may be accessible to the PglB oligosaccharyltransferase in the folded state.
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===Crystal Structure of Peb3 from Campylobacter jejuni===
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Structural context for protein N-glycosylation in bacteria: The structure of PEB3, an adhesin from Campylobacter jejuni.,Rangarajan ES, Bhatia S, Watson DC, Munger C, Cygler M, Matte A, Young NM Protein Sci. 2007 May;16(5):990-5. PMID:17456748<ref>PMID:17456748</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17456748}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2hxw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17456748 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17456748}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2HXW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXW OCA].
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==Reference==
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Structural context for protein N-glycosylation in bacteria: The structure of PEB3, an adhesin from Campylobacter jejuni., Rangarajan ES, Bhatia S, Watson DC, Munger C, Cygler M, Matte A, Young NM, Protein Sci. 2007 May;16(5):990-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17456748 17456748]
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[[Category: Campylobacter jejuni]]
[[Category: Campylobacter jejuni]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
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[[Category: Bhatia S]]
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[[Category: Bhatia, S.]]
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[[Category: Cygler M]]
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[[Category: Cygler, M.]]
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[[Category: Matte A]]
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[[Category: Matte, A.]]
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[[Category: Munger C]]
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[[Category: Munger, C.]]
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[[Category: Rangarajan ES]]
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[[Category: Rangarajan, E S.]]
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[[Category: Watson DC]]
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[[Category: Watson, D C.]]
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[[Category: Young NM]]
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[[Category: Young, N M.]]
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[[Category: Bsgi]]
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
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[[Category: N-glycosylation]]
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[[Category: Peb3]]
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[[Category: Periplasmic binding protein]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:39:47 2008''
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Current revision

Crystal Structure of Peb3 from Campylobacter jejuni

PDB ID 2hxw

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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