2je0

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{{Seed}}
 
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[[Image:2je0.png|left|200px]]
 
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==Crystal Structure of pp32==
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The line below this paragraph, containing "STRUCTURE_2je0", creates the "Structure Box" on the page.
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<StructureSection load='2je0' size='340' side='right'caption='[[2je0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2je0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JE0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2je0| PDB=2je0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2je0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2je0 OCA], [https://pdbe.org/2je0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2je0 RCSB], [https://www.ebi.ac.uk/pdbsum/2je0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2je0 ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF PP32===
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== Function ==
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[https://www.uniprot.org/uniprot/AN32A_HUMAN AN32A_HUMAN] Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.<ref>PMID:15642345</ref> <ref>PMID:10400610</ref> <ref>PMID:11360199</ref> <ref>PMID:17557114</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17567741 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2je0_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17567741}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2JE0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE0 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2je0 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins., Huyton T, Wolberger C, Protein Sci. 2007 Jul;16(7):1308-15. Epub 2007 Jun 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17567741 17567741]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Huyton, T.]]
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[[Category: Huyton T]]
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[[Category: Wolberger, C.]]
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[[Category: Wolberger C]]
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[[Category: Anp32a]]
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[[Category: Lanp]]
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[[Category: Leucine-rich repeat]]
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[[Category: Lrr]]
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[[Category: Mapmodulin]]
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[[Category: Nuclear protein]]
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[[Category: Phapi]]
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[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:47:18 2008''
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Current revision

Crystal Structure of pp32

PDB ID 2je0

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