1z0c

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{{Seed}}
 
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[[Image:1z0c.png|left|200px]]
 
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==Crystal Structure of A. fulgidus Lon proteolytic domain D508A mutant==
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The line below this paragraph, containing "STRUCTURE_1z0c", creates the "Structure Box" on the page.
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<StructureSection load='1z0c' size='340' side='right'caption='[[1z0c]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z0c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z0C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z0c OCA], [https://pdbe.org/1z0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z0c RCSB], [https://www.ebi.ac.uk/pdbsum/1z0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z0c ProSAT]</span></td></tr>
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{{STRUCTURE_1z0c| PDB=1z0c | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of A. fulgidus Lon proteolytic domain D508A mutant===
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[https://www.uniprot.org/uniprot/LONB_ARCFU LONB_ARCFU] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 16002085 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z0/1z0c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_16002085}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z0c ConSurf].
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1Z0C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0C OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Atomic-resolution crystal structure of the proteolytic domain of Archaeoglobus fulgidus lon reveals the conformational variability in the active sites of lon proteases., Botos I, Melnikov EE, Cherry S, Kozlov S, Makhovskaya OV, Tropea JE, Gustchina A, Rotanova TV, Wlodawer A, J Mol Biol. 2005 Aug 5;351(1):144-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16002085 16002085]
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Pathological crystallography: case studies of several unusual macromolecular crystals., Dauter Z, Botos I, LaRonde-LeBlanc N, Wlodawer A, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):967-75. Epub 2005, Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15983420 15983420]
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[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
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[[Category: Endopeptidase La]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Botos I]]
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[[Category: Botos, I.]]
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[[Category: Cherry S]]
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[[Category: Cherry, S.]]
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[[Category: Gustchina A]]
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[[Category: Gustchina, A.]]
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[[Category: Kozlov S]]
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[[Category: Kozlov, S.]]
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[[Category: Makhovskaya OV]]
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[[Category: Makhovskaya, O V.]]
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[[Category: Melnikov EE]]
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[[Category: Melnikov, E E.]]
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[[Category: Rotanova TV]]
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[[Category: Rotanova, T V.]]
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[[Category: Tropea JE]]
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[[Category: Tropea, J E.]]
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[[Category: Wlodawer A]]
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[[Category: Wlodawer, A.]]
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[[Category: Atp-dependent protease]]
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[[Category: B-type lon]]
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[[Category: Catalytic ser-lys dyad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:12:25 2008''
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Current revision

Crystal Structure of A. fulgidus Lon proteolytic domain D508A mutant

PDB ID 1z0c

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