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1tdj

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{{Seed}}
 
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[[Image:1tdj.png|left|200px]]
 
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==THREONINE DEAMINASE (BIOSYNTHETIC) FROM E. COLI==
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The line below this paragraph, containing "STRUCTURE_1tdj", creates the "Structure Box" on the page.
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<StructureSection load='1tdj' size='340' side='right'caption='[[1tdj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tdj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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{{STRUCTURE_1tdj| PDB=1tdj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdj OCA], [https://pdbe.org/1tdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdj RCSB], [https://www.ebi.ac.uk/pdbsum/1tdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ILVA_ECOLI ILVA_ECOLI] Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.<ref>PMID:13405870</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/td/1tdj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tdj ConSurf].
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<div style="clear:both"></div>
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===THREONINE DEAMINASE (BIOSYNTHETIC) FROM E. COLI===
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==See Also==
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*[[Deaminase 3D structures|Deaminase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9562556}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9562556 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_9562556}}
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==About this Structure==
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1TDJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDJ OCA].
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==Reference==
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Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase., Gallagher DT, Gilliland GL, Xiao G, Zondlo J, Fisher KE, Chinchilla D, Eisenstein E, Structure. 1998 Apr 15;6(4):465-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9562556 9562556]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Threonine ammonia-lyase]]
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[[Category: Eisenstein E]]
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[[Category: Eisenstein, E.]]
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[[Category: Gallagher DT]]
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[[Category: Gallagher, D T.]]
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[[Category: Gilliland GL]]
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[[Category: Gilliland, G L.]]
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[[Category: Xiao G]]
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[[Category: Xiao, G.]]
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[[Category: Allostery]]
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[[Category: Cooperative]]
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[[Category: Isoleucine biosynthesis]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Regulation]]
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[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:15:22 2008''
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Current revision

THREONINE DEAMINASE (BIOSYNTHETIC) FROM E. COLI

PDB ID 1tdj

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