1xed

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{{Seed}}
 
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[[Image:1xed.png|left|200px]]
 
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==Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR==
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The line below this paragraph, containing "STRUCTURE_1xed", creates the "Structure Box" on the page.
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<StructureSection load='1xed' size='340' side='right'caption='[[1xed]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xed]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XED FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1xed| PDB=1xed | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xed OCA], [https://pdbe.org/1xed PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xed RCSB], [https://www.ebi.ac.uk/pdbsum/1xed PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xed ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xed_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xed ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The polymeric immunoglobulin receptor (pIgR) is a type I transmembrane protein that delivers dimeric IgA (dIgA) and pentameric IgM to mucosal secretions. Here, we report the 1.9 A resolution X-ray crystal structure of the N-terminal domain of human pIgR, which binds dIgA in the absence of other pIgR domains with an equilibrium dissociation constant of 300 nM. The structure of pIgR domain 1 reveals a folding topology similar to immunoglobulin variable domains, but with differences in the counterparts of the complementarity determining regions (CDRs), including a helical turn in CDR1 and a CDR3 loop that points away from the other CDRs. The unusual CDR3 loop position prevents dimerization analogous to the pairing of antibody variable heavy and variable light domains. The pIgR domain 1 structure allows interpretation of previous mutagenesis results and structure-based comparisons between pIgR and other IgA receptors.
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===Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR===
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Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor.,Hamburger AE, West AP Jr, Bjorkman PJ Structure. 2004 Nov;12(11):1925-35. PMID:15530357<ref>PMID:15530357</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15530357}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1xed" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15530357 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15530357}}
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: IgA nephropathy, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173880 173880]]
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==About this Structure==
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1XED is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XED OCA].
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==Reference==
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Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor., Hamburger AE, West AP Jr, Bjorkman PJ, Structure. 2004 Nov;12(11):1925-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15530357 15530357]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bjorkman, P J.]]
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[[Category: Bjorkman PJ]]
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[[Category: Hamburger, A E.]]
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[[Category: Hamburger AE]]
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[[Category: Jr., A P.West.]]
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[[Category: West Jr AP]]
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[[Category: Ig-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:17:02 2008''
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Current revision

Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR

PDB ID 1xed

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