2v7f

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{{Seed}}
 
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[[Image:2v7f.png|left|200px]]
 
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==Structure of P. abyssi RPS19 protein==
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The line below this paragraph, containing "STRUCTURE_2v7f", creates the "Structure Box" on the page.
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<StructureSection load='2v7f' size='340' side='right'caption='[[2v7f]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_2v7f| PDB=2v7f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7f OCA], [https://pdbe.org/2v7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7f RCSB], [https://www.ebi.ac.uk/pdbsum/2v7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RS19E_PYRAB RS19E_PYRAB] May be involved in maturation of the 30S ribosomal subunit.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/2v7f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v7f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Diamond-Blackfan anemia (DBA) is a rare congenital disease linked to mutations in the ribosomal protein genes rps19, rps24 and rps17. It belongs to the emerging class of ribosomal disorders. To understand the impact of DBA mutations on RPS19 function, we have solved the crystal structure of RPS19 from Pyrococcus abyssi. The protein forms a five alpha-helix bundle organized around a central amphipathic alpha-helix, which corresponds to the DBA mutation hot spot. From the structure, we classify DBA mutations relative to their respective impact on protein folding (class I) or on surface properties (class II). Class II mutations cluster into two conserved basic patches. In vivo analysis in yeast demonstrates an essential role for class II residues in the incorporation into pre-40S ribosomal particles. This data indicate that missense mutations in DBA primarily affect the capacity of the protein to be incorporated into pre-ribosomes, thus blocking maturation of the pre-40S particles.
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===STRUCTURE OF P. ABYSSI RPS19 PROTEIN===
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Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19.,Gregory LA, Aguissa-Toure AH, Pinaud N, Legrand P, Gleizes PE, Fribourg S Nucleic Acids Res. 2007;35(17):5913-21. Epub 2007 Aug 28. PMID:17726054<ref>PMID:17726054</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2v7f" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17726054}}, adds the Publication Abstract to the page
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*[[Ribosomal protein S19|Ribosomal protein S19]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17726054 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17726054}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2V7F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7F OCA].
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==Reference==
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Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19., Gregory LA, Aguissa-Toure AH, Pinaud N, Legrand P, Gleizes PE, Fribourg S, Nucleic Acids Res. 2007;35(17):5913-21. Epub 2007 Aug 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17726054 17726054]
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[[Category: Pyrococcus abyssi]]
[[Category: Pyrococcus abyssi]]
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[[Category: Single protein]]
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[[Category: Aguissa-Toure AH]]
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[[Category: Aguissa-Toure, A H.]]
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[[Category: Fribourg S]]
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[[Category: Fribourg, S.]]
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[[Category: Gleizes PE]]
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[[Category: Gleizes, P E.]]
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[[Category: Gregory LA]]
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[[Category: Gregory, L A.]]
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[[Category: Legrand P]]
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[[Category: Legrand, P.]]
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[[Category: Pinaud N]]
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[[Category: Pinaud, N.]]
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[[Category: Diamond blackfan anemia small ribosomal subunit]]
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[[Category: Ribosomal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:19:38 2008''
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Current revision

Structure of P. abyssi RPS19 protein

PDB ID 2v7f

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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