2jp8

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{{Seed}}
 
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[[Image:2jp8.png|left|200px]]
 
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==Angiotensin 1-7==
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The line below this paragraph, containing "STRUCTURE_2jp8", creates the "Structure Box" on the page.
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<StructureSection load='2jp8' size='340' side='right'caption='[[2jp8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JP8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp8 OCA], [https://pdbe.org/2jp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jp8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jp8 ProSAT]</span></td></tr>
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{{STRUCTURE_2jp8| PDB=2jp8 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ANGT_HUMAN ANGT_HUMAN] Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:[https://omim.org/entry/145500 145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:[https://omim.org/entry/267430 267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ANGT_HUMAN ANGT_HUMAN] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref> Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref> Angiotensin-3: stimulates aldosterone release.<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref> Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the complete sequence-specific hydrogen NMR assignments of vasoactive peptide angiotensin-(1-7) (Ang-(1-7)). Assignments of the majority of the resonances were accomplished by COSY, TOCSY, and ROESY peak coordinates at 400MHz and 600MHz. Long-side-chain amino acid spin system identification was facilitated by long-range coherence transfer experiments (TOCSY). Problems with overlapped resonance signals were solved by analysis of heteronuclear 2D experiments (HSQC and HMBC). Nuclear Overhauser effects (NOE) results were used to probe peptide conformation. We show that the inclusion of the angiotensin-(1-7) tyrosine residue is favored in inclusion complexes with beta-cyclodextrin. QM/MM simulations at the DFTB/UFF level confirm the experimental NMR findings and provide detailed structural information on these compounds in aqueous solution.
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===Angiotensin 1-7===
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Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies.,Lula I, Denadai AL, Resende JM, de Sousa FB, de Lima GF, Pilo-Veloso D, Heine T, Duarte HA, Santos RA, Sinisterra RD Peptides. 2007 Nov;28(11):2199-210. Epub 2007 Aug 19. PMID:17904691<ref>PMID:17904691</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2jp8" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17904691}}, adds the Publication Abstract to the page
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*[[Serpin 3D structures|Serpin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17904691 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17904691}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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2JP8 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP8 OCA].
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[[Category: Large Structures]]
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[[Category: Denadai AL]]
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==Reference==
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[[Category: Duarte HA]]
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Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies., Lula I, Denadai AL, Resende JM, de Sousa FB, de Lima GF, Pilo-Veloso D, Heine T, Duarte HA, Santos RA, Sinisterra RD, Peptides. 2007 Nov;28(11):2199-210. Epub 2007 Aug 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17904691 17904691]
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[[Category: Heine T]]
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[[Category: Single protein]]
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[[Category: Lula I]]
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[[Category: Denadai, A L.]]
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[[Category: Pilo-Veloso D]]
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[[Category: Duarte, H A.]]
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[[Category: Resende JM]]
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[[Category: Heine, T.]]
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[[Category: Santos RAS]]
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[[Category: Lima, G F.de.]]
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[[Category: Sinesterra RD]]
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[[Category: Lula, I.]]
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[[Category: De Lima GF]]
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[[Category: Pilo-Veloso, D.]]
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[[Category: De Souza FB]]
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[[Category: Resende, J M.]]
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[[Category: Santos, R A.S.]]
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[[Category: Sinesterra, R D.]]
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[[Category: Souza, F B.de.]]
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[[Category: Bend]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:23:07 2008''
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Current revision

Angiotensin 1-7

PDB ID 2jp8

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