1p5o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:55, 29 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1p5o.png|left|200px]]
 
-
<!--
+
==Solution Structure of HCV IRES Domain II==
-
The line below this paragraph, containing "STRUCTURE_1p5o", creates the "Structure Box" on the page.
+
<StructureSection load='1p5o' size='340' side='right'caption='[[1p5o]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1p5o]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P5O FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p5o OCA], [https://pdbe.org/1p5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p5o RCSB], [https://www.ebi.ac.uk/pdbsum/1p5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p5o ProSAT]</span></td></tr>
-
{{STRUCTURE_1p5o| PDB=1p5o | SCENE= }}
+
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Complex RNA structures regulate many biological processes, but are often too large for structure determination by NMR methods. The 5' untranslated region (5' UTR) of the hepatitis C viral (HCV) RNA genome contains an internal ribosome entry site (IRES) that binds to 40S ribosomal subunits with high affinity and specificity to control translation. Domain II of the HCV IRES forms a 25-kDa folded subdomain that may alter ribosome conformation. We report here the structure of domain II as determined using an NMR approach that combines short- and long-range structural data. Domain II adopts a distorted L-shape structure, and its overall shape in the free form is markedly similar to its 40S subunit-bound form; this suggests how domain II may modulate 40S subunit conformation. The results show how NMR can be used for structural analysis of large biological RNAs.
-
===Solution Structure of HCV IRES Domain II===
+
Structure of HCV IRES domain II determined by NMR.,Lukavsky PJ, Kim I, Otto GA, Puglisi JD Nat Struct Biol. 2003 Dec;10(12):1033-8. Epub 2003 Oct 26. PMID:14578934<ref>PMID:14578934</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_14578934}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1p5o" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 14578934 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_14578934}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5O OCA].
+
[[Category: Kim I]]
-
 
+
[[Category: Lukavsky PJ]]
-
==Reference==
+
[[Category: Otto GA]]
-
Structure of HCV IRES domain II determined by NMR., Lukavsky PJ, Kim I, Otto GA, Puglisi JD, Nat Struct Biol. 2003 Dec;10(12):1033-8. Epub 2003 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14578934 14578934]
+
[[Category: Puglisi JD]]
-
[[Category: Kim, I.]]
+
-
[[Category: Lukavsky, P J.]]
+
-
[[Category: Otto, G A.]]
+
-
[[Category: Puglisi, J D.]]
+
-
[[Category: Hairpin loop]]
+
-
[[Category: Hepatitis c virus]]
+
-
[[Category: Internal ribosome entry site]]
+
-
[[Category: Loop e motif]]
+
-
[[Category: Ribonucleic acid]]
+
-
[[Category: Trna]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:25:15 2008''
+

Current revision

Solution Structure of HCV IRES Domain II

PDB ID 1p5o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p5o"
Personal tools