This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ocr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1ocr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ocr, resolution 2.35&Aring;" /> '''BOVINE HEART CYTOCHR...)
Current revision (05:46, 17 April 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ocr.gif|left|200px]]<br /><applet load="1ocr" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1ocr, resolution 2.35&Aring;" />
 
-
'''BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE'''<br />
 
-
==Overview==
+
==BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE==
-
Crystal structures of bovine heart cytochrome c oxidase in the fully, oxidized, fully reduced, azide-bound, and carbon monoxide-bound states, were determined at 2.30, 2.35, 2.9, and 2.8 angstrom resolution, respectively. An aspartate residue apart from the O2 reduction site, exchanges its effective accessibility to the matrix aqueous phase for one, to the cytosolic phase concomitantly with a significant decrease in the pK, of its carboxyl group, on reduction of the metal sites. The movement, indicates the aspartate as the proton pumping site. A tyrosine acidified, by a covalently linked imidazole nitrogen is a possible proton donor for, the O2 reduction by the enzyme.
+
<StructureSection load='1ocr' size='340' side='right'caption='[[1ocr]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1ocr]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OCR FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=HEA:HEME-A'>HEA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ocr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ocr OCA], [https://pdbe.org/1ocr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ocr RCSB], [https://www.ebi.ac.uk/pdbsum/1ocr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ocr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/COX1_BOVIN COX1_BOVIN] Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1ocr_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ocr ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1OCR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CU, MG, NA, ZN and HEA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytochrome-c_oxidase Cytochrome-c oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.9.3.1 1.9.3.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OCR OCA].
+
*[[Cytochrome c oxidase 3D structures|Cytochrome c oxidase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase., Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T, Science. 1998 Jun 12;280(5370):1723-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9624044 9624044]
+
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Cytochrome-c oxidase]]
+
[[Category: Large Structures]]
-
[[Category: Protein complex]]
+
[[Category: Tsukihara T]]
-
[[Category: Tsukihara, T.]]
+
[[Category: Yao M]]
-
[[Category: Yao, M.]]
+
-
[[Category: CU]]
+
-
[[Category: HEA]]
+
-
[[Category: MG]]
+
-
[[Category: NA]]
+
-
[[Category: ZN]]
+
-
[[Category: cytochrome c oxidase]]
+
-
[[Category: oxidoreductase (cytochrome(c)-oxygen)]]
+
-
[[Category: reduced]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 22:55:00 2007''
+

Current revision

BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE

PDB ID 1ocr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ocr"
Personal tools