2f2j

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{{Seed}}
 
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[[Image:2f2j.png|left|200px]]
 
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==Solution structure of [W19K, P20N, V21K]-kalata B1==
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The line below this paragraph, containing "STRUCTURE_2f2j", creates the "Structure Box" on the page.
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<StructureSection load='2f2j' size='340' side='right'caption='[[2f2j]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oldenlandia_affinis Oldenlandia affinis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2j OCA], [https://pdbe.org/2f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2j RCSB], [https://www.ebi.ac.uk/pdbsum/2f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2j ProSAT]</span></td></tr>
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{{STRUCTURE_2f2j| PDB=2f2j | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAB1_OLDAF KAB1_OLDAF] Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S.aureus with a minimum inhibition concentration of approximately 0.2 microM. Relatively ineffective against Gram-negative bacteria such as E.coli and P.aeruginosa. Inhibitory effect on the growth and development of larvae from H.punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost.<ref>PMID:17534989</ref> <ref>PMID:12779323</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cyclotide family of plant proteins is of interest because of their unique topology, which combines a head-to-tail cyclic backbone with an embedded cystine knot, and because their remarkable chemical and biological properties make them ideal candidates as grafting templates for biologically active peptide epitopes. The present study describes the first steps towards exploiting the cyclotide framework by synthesizing and structurally characterizing two grafted analogues of the cyclotide kalata B1. The modified peptides have polar or charged residues substituted for residues that form part of a surface-exposed hydrophobic patch that plays a significant role in the folding and biological activity of kalata B1. Both analogues retain the native cyclotide fold, but lack the undesired haemolytic activity of their parent molecule, kalata B1. This finding confirms the tolerance of the cyclotide framework to residue substitutions and opens up possibilities for the substitution of biologically active peptide epitopes into the framework.
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===Solution structure of [W19K, P20N, V21K]-kalata B1===
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Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.,Clark RJ, Daly NL, Craik DJ Biochem J. 2006 Feb 15;394(Pt 1):85-93. PMID:16300479<ref>PMID:16300479</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2f2j" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16300479 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16300479}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2F2J is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2J OCA].
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[[Category: Oldenlandia affinis]]
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[[Category: Clark RJ]]
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==Reference==
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[[Category: Craik DJ]]
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Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design., Clark RJ, Daly NL, Craik DJ, Biochem J. 2006 Feb 15;394(Pt 1):85-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16300479 16300479]
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[[Category: Daly NL]]
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[[Category: Single protein]]
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[[Category: Clark, R J.]]
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[[Category: Craik, D J.]]
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[[Category: Daly, N L.]]
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[[Category: Beta-hairpin]]
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[[Category: Circular backbone]]
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[[Category: Cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:47:34 2008''
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Current revision

Solution structure of [W19K, P20N, V21K]-kalata B1

PDB ID 2f2j

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