1s9l

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{{Seed}}
 
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[[Image:1s9l.png|left|200px]]
 
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==NMR Solution Structure of a Parallel LNA Quadruplex==
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The line below this paragraph, containing "STRUCTURE_1s9l", creates the "Structure Box" on the page.
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<StructureSection load='1s9l' size='340' side='right'caption='[[1s9l]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s9l]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S9L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene>, <scene name='pdbligand=TLN:[(1R,3R,4R,7S)-7-HYDROXY-3-(THYMIN-1-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>TLN</scene></td></tr>
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{{STRUCTURE_1s9l| PDB=1s9l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9l OCA], [https://pdbe.org/1s9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s9l RCSB], [https://www.ebi.ac.uk/pdbsum/1s9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s9l ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of a locked nucleic acid (LNA) quadruplex, formed by the oligomer d(TGGGT), containing only conformationally restricted LNA residues is reported. NMR and CD spectroscopy, as well as molecular dynamics and mechanic calculations, has been used to characterize the complex. The molecule adopts a parallel stranded conformation with a 4-fold rotational symmetry, showing a right-handed helicity and the guanine residues in an almost planar conformation with three well-defined G-tetrads. The thermal stability of Q-LNA has been found to be comparable with that of [r(UGGGU)]4, while a T(m) increment of 20 degrees C with respect to the corresponding DNA quadruplex structure [d(TGGGT)]4 has been observed. The structural features of the LNA quadruplex reported here may open new perspectives for the biological application of LNAs as novel versatile tools to design aptamer or catalyst oligonucleotides.
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===NMR Solution Structure of a Parallel LNA Quadruplex===
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NMR solution structure of a parallel LNA quadruplex.,Randazzo A, Esposito V, Ohlenschlager O, Ramachandran R, Mayola L Nucleic Acids Res. 2004 Jun 4;32(10):3083-92. Print 2004. PMID:15181173<ref>PMID:15181173</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15181173}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1s9l" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15181173 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15181173}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9L OCA].
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[[Category: Esposito V]]
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[[Category: Mayola L]]
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==Reference==
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[[Category: Ohlenschlager O]]
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NMR solution structure of a parallel LNA quadruplex., Randazzo A, Esposito V, Ohlenschlager O, Ramachandran R, Mayola L, Nucleic Acids Res. 2004 Jun 4;32(10):3083-92. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15181173 15181173]
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[[Category: Ramachandran R]]
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[[Category: Esposito, V.]]
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[[Category: Randazzo A]]
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[[Category: Mayola, L.]]
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[[Category: Ohlenschlager, O.]]
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[[Category: Ramachandran, R.]]
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[[Category: Randazzo, A.]]
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[[Category: Lna]]
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[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:52:47 2008''
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Current revision

NMR Solution Structure of a Parallel LNA Quadruplex

PDB ID 1s9l

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