2ewl

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{{Seed}}
 
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[[Image:2ewl.png|left|200px]]
 
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==Solution structure of the C-terminal domain (monomer) of the HPV45 oncoprotein E7==
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The line below this paragraph, containing "STRUCTURE_2ewl", creates the "Structure Box" on the page.
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<StructureSection load='2ewl' size='340' side='right'caption='[[2ewl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ewl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_45 Human papillomavirus 45]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EWL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2ewl| PDB=2ewl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ewl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ewl OCA], [https://pdbe.org/2ewl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ewl RCSB], [https://www.ebi.ac.uk/pdbsum/2ewl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ewl ProSAT]</span></td></tr>
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</table>
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===Solution structure of the C-terminal domain (monomer) of the HPV45 oncoprotein E7===
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== Function ==
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[https://www.uniprot.org/uniprot/VE7_HPV45 VE7_HPV45] E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16636661}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16636661 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/2ewl_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16636661}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2EWL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWL OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ewl ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Solution structure of the partially folded high-risk human papilloma virus 45 oncoprotein E7., Ohlenschlager O, Seiboth T, Zengerling H, Briese L, Marchanka A, Ramachandran R, Baum M, Korbas M, Meyer-Klaucke W, Durst M, Gorlach M, Oncogene. 2006 Sep 28;25(44):5953-9. Epub 2006 Apr 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16636661 16636661]
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</StructureSection>
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[[Category: Human papillomavirus]]
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[[Category: Human papillomavirus 45]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gorlach, M.]]
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[[Category: Gorlach M]]
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[[Category: Ohlenschlager, O.]]
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[[Category: Ohlenschlager O]]
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[[Category: E7]]
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[[Category: Hpv]]
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[[Category: Oncoprotein]]
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[[Category: Zinc binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:53:42 2008''
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Current revision

Solution structure of the C-terminal domain (monomer) of the HPV45 oncoprotein E7

PDB ID 2ewl

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