1r6e

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{{Seed}}
 
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[[Image:1r6e.png|left|200px]]
 
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==Solution structure of the catalytic domain of SopE2==
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The line below this paragraph, containing "STRUCTURE_1r6e", creates the "Structure Box" on the page.
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<StructureSection load='1r6e' size='340' side='right'caption='[[1r6e]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R6E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6e OCA], [https://pdbe.org/1r6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r6e RCSB], [https://www.ebi.ac.uk/pdbsum/1r6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6e ProSAT]</span></td></tr>
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{{STRUCTURE_1r6e| PDB=1r6e | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the catalytic domain of SopE2===
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[https://www.uniprot.org/uniprot/SOPE2_SALTY SOPE2_SALTY] Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.<ref>PMID:10931274</ref> <ref>PMID:15321998</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15379540 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15379540}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r6e ConSurf].
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1R6E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6E OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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solution structure, backbone dynamics, and interaction with Cdc42 of Salmonella guanine nucleotide exchange factor SopE2., Williams C, Galyov EE, Bagby S, Biochemistry. 2004 Sep 28;43(38):11998-2008. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15379540 15379540]
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__TOC__
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[[Category: Salmonella typhimurium lt2]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bagby, S.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Galyov, E E.]]
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[[Category: Bagby S]]
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[[Category: Williams, C.]]
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[[Category: Galyov EE]]
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[[Category: Guanine nucleotide exchange factor,type iii secretion]]
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[[Category: Williams C]]
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[[Category: Invasion]]
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[[Category: Salmonella]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:54:01 2008''
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Current revision

Solution structure of the catalytic domain of SopE2

PDB ID 1r6e

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