1t3j

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{{Seed}}
 
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[[Image:1t3j.png|left|200px]]
 
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==Mitofusin domain HR2 V686M/I708M mutant==
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The line below this paragraph, containing "STRUCTURE_1t3j", creates the "Structure Box" on the page.
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<StructureSection load='1t3j' size='340' side='right'caption='[[1t3j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3j OCA], [https://pdbe.org/1t3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3j RCSB], [https://www.ebi.ac.uk/pdbsum/1t3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3j ProSAT]</span></td></tr>
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{{STRUCTURE_1t3j| PDB=1t3j | SCENE= }}
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</table>
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== Function ==
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===Mitofusin domain HR2 V686M/I708M mutant===
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[https://www.uniprot.org/uniprot/MFN1_MOUSE MFN1_MOUSE] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:12527753</ref> <ref>PMID:15297672</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_15297672}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15297672 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15297672}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3j ConSurf].
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1T3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structural basis of mitochondrial tethering by mitofusin complexes., Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC, Science. 2004 Aug 6;305(5685):858-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15297672 15297672]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Chan DC]]
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[[Category: Chan, D C.]]
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[[Category: Chen H]]
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[[Category: Chen, H.]]
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[[Category: Detmer SA]]
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[[Category: Detmer, S A.]]
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[[Category: Kaiser JT]]
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[[Category: Kaiser, J T.]]
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[[Category: Koshiba T]]
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[[Category: Koshiba, T.]]
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[[Category: McCaffery JM]]
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[[Category: McCaffery, J M.]]
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[[Category: Coiled coil antiparallel]]
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[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:58:12 2008''
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Current revision

Mitofusin domain HR2 V686M/I708M mutant

PDB ID 1t3j

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