1pdg

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{{Seed}}
 
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[[Image:1pdg.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB==
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The line below this paragraph, containing "STRUCTURE_1pdg", creates the "Structure Box" on the page.
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<StructureSection load='1pdg' size='340' side='right'caption='[[1pdg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pdg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PDG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdg OCA], [https://pdbe.org/1pdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pdg RCSB], [https://www.ebi.ac.uk/pdbsum/1pdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdg ProSAT]</span></td></tr>
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{{STRUCTURE_1pdg| PDB=1pdg | SCENE= }}
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</table>
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== Disease ==
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===CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB===
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[https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_1396586}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 1396586 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_1396586}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pd/1pdg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1PDG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDG OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pdg ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Crystal structure of human platelet-derived growth factor BB., Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M, EMBO J. 1992 Nov;11(11):3921-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1396586 1396586]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Darcy, A D.]]
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[[Category: Darcy AD]]
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[[Category: Eggimann, B.]]
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[[Category: Eggimann B]]
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[[Category: Hosnag, M.]]
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[[Category: Hosnag M]]
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[[Category: Oefner, C.]]
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[[Category: Oefner C]]
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[[Category: Winkler, F K.]]
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[[Category: Winkler FK]]
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[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:00:53 2008''
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Current revision

CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB

PDB ID 1pdg

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