2om5

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{{Seed}}
 
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[[Image:2om5.png|left|200px]]
 
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==N-Terminal Fragment of Human TAX1==
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The line below this paragraph, containing "STRUCTURE_2om5", creates the "Structure Box" on the page.
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<StructureSection load='2om5' size='340' side='right'caption='[[2om5]], [[Resolution|resolution]] 3.07&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2om5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OM5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.07&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2om5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2om5 OCA], [https://pdbe.org/2om5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2om5 RCSB], [https://www.ebi.ac.uk/pdbsum/2om5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2om5 ProSAT]</span></td></tr>
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{{STRUCTURE_2om5| PDB=2om5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CNTN2_HUMAN CNTN2_HUMAN] May play a role in the initial growth and guidance of axons. May be involved in cell adhesion.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/2om5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2om5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human TAG-1 is a neural cell adhesion molecule that is crucial for the development of the nervous system during embryogenesis. It consists of six immunoglobulin-like and four fibronectin III-like domains and is anchored to the membrane by glycosylphosphatidylinositol. Herein we present the crystal structure of the four N-terminal immunoglobulin-like domains of TAG-1 (TAG-1(Ig1-4)), known to be important in heterophilic and homophilic macromolecular interactions. The contacts of neighboring molecules within the crystal were investigated. A comparison with the structure of the chicken ortholog resulted in an alternative mode for the molecular mechanism of homophilic TAG-1 interaction. This mode of TAG-1 homophilic interaction is based on dimer formation rather than formation of a molecular zipper as proposed for the chicken ortholog.
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===N-Terminal Fragment of Human TAX1===
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The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.,Mortl M, Sonderegger P, Diederichs K, Welte W Protein Sci. 2007 Oct;16(10):2174-83. Epub 2007 Aug 31. PMID:17766378<ref>PMID:17766378</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17766378}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2om5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17766378 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17766378}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2OM5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OM5 OCA].
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==Reference==
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The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction., Mortl M, Sonderegger P, Diederichs K, Welte W, Protein Sci. 2007 Oct;16(10):2174-83. Epub 2007 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17766378 17766378]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Diederichs, K.]]
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[[Category: Diederichs K]]
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[[Category: Moertl, M.]]
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[[Category: Moertl M]]
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[[Category: Sonderegger, P.]]
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[[Category: Sonderegger P]]
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[[Category: Welte, W.]]
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[[Category: Welte W]]
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[[Category: Cell adhesion]]
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[[Category: Fibronectin]]
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[[Category: Ig-like c2-type]]
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[[Category: Immunoglobulin superfamily]]
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[[Category: Membrane protein]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:03:46 2008''
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Current revision

N-Terminal Fragment of Human TAX1

PDB ID 2om5

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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