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1toc

From Proteopedia

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{{Seed}}
 
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[[Image:1toc.png|left|200px]]
 
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==STRUCTURE OF SERINE PROTEINASE==
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The line below this paragraph, containing "STRUCTURE_1toc", creates the "Structure Box" on the page.
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<StructureSection load='1toc' size='340' side='right'caption='[[1toc]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1toc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TOC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1toc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1toc OCA], [https://pdbe.org/1toc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1toc RCSB], [https://www.ebi.ac.uk/pdbsum/1toc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1toc ProSAT]</span></td></tr>
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{{STRUCTURE_1toc| PDB=1toc | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/to/1toc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1toc ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF SERINE PROTEINASE===
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==See Also==
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*[[Proteinase 3D structures|Proteinase 3D structures]]
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*[[Thrombin 3D Structures|Thrombin 3D Structures]]
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_8947023}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 8947023 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8947023}}
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==About this Structure==
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1TOC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOC OCA].
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==Reference==
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The ornithodorin-thrombin crystal structure, a key to the TAP enigma?, van de Locht A, Stubbs MT, Bode W, Friedrich T, Bollschweiler C, Hoffken W, Huber R, EMBO J. 1996 Nov 15;15(22):6011-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8947023 8947023]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Ornithodoros moubata]]
[[Category: Ornithodoros moubata]]
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[[Category: Protein complex]]
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[[Category: Bode W]]
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[[Category: Thrombin]]
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[[Category: Huber R]]
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[[Category: Bode, W.]]
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[[Category: Van De Locht A]]
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[[Category: Huber, R.]]
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[[Category: Locht, A Van De.]]
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[[Category: Acute phase]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: Hydrolase]]
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[[Category: Kringle]]
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[[Category: Liver]]
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[[Category: Serine protease kunitz-like inhibitor]]
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[[Category: Signal]]
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[[Category: Vitamin k]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:03:55 2008''
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Current revision

STRUCTURE OF SERINE PROTEINASE

PDB ID 1toc

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