1rqj

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{{Seed}}
 
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[[Image:1rqj.png|left|200px]]
 
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==Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate==
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The line below this paragraph, containing "STRUCTURE_1rqj", creates the "Structure Box" on the page.
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<StructureSection load='1rqj' size='340' side='right'caption='[[1rqj]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RQJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>
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{{STRUCTURE_1rqj| PDB=1rqj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqj OCA], [https://pdbe.org/1rqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rqj RCSB], [https://www.ebi.ac.uk/pdbsum/1rqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPA_ECOLI ISPA_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/1rqj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rqj ConSurf].
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<div style="clear:both"></div>
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===Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate===
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14672944}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14672944 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14672944}}
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==About this Structure==
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1RQJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQJ OCA].
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==Reference==
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Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis., Hosfield DJ, Zhang Y, Dougan DR, Broun A, Tari LW, Swanson RV, Finn J, J Biol Chem. 2004 Mar 5;279(10):8526-9. Epub 2003 Dec 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14672944 14672944]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Geranyltranstransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Brooun A]]
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[[Category: Brooun, A.]]
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[[Category: Dougan DR]]
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[[Category: Dougan, D R.]]
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[[Category: Finn J]]
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[[Category: Finn, J.]]
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[[Category: Hosfield DJ]]
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[[Category: Hosfield, D J.]]
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[[Category: Swanson RV]]
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[[Category: Swanson, R V.]]
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[[Category: Tari LW]]
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[[Category: Tari, L W.]]
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[[Category: Zhang Y]]
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[[Category: Zhang, Y.]]
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[[Category: Bisphosphonate]]
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[[Category: Isoprenyl synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:05:23 2008''
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Current revision

Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate

PDB ID 1rqj

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