2bzv

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{{Seed}}
 
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[[Image:2bzv.png|left|200px]]
 
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==Human Enteric Adenovirus Serotype 41 Short Fiber Head (pH8)==
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The line below this paragraph, containing "STRUCTURE_2bzv", creates the "Structure Box" on the page.
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<StructureSection load='2bzv' size='340' side='right'caption='[[2bzv]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_41 Human adenovirus 41]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzv OCA], [https://pdbe.org/2bzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bzv RCSB], [https://www.ebi.ac.uk/pdbsum/2bzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzv ProSAT]</span></td></tr>
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{{STRUCTURE_2bzv| PDB=2bzv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPIK2_ADE41 SPIK2_ADE41] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bzv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bzv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human enteric adenoviruses of species F contain two fibers in the same virion, a long fiber which binds to coxsackievirus and adenovirus receptor (CAR) and a short fiber of unknown function. We have determined the high-resolution crystal structure of the short fiber head of human adenovirus serotype 41 (Ad41). The short fiber head has the characteristic fold of other known fiber heads but has three unusual features. First, it has much shorter loops between the beta-strands. Second, one of the usually well-ordered beta-strands on the distal face of the fiber head is highly disordered and this same region is sensitive to digestion with pepsin, an enzyme occurring naturally in the intestinal tract, the physiological environment of Ad41. Third, the AB loop has a deletion giving it a distinct conformation incompatible with CAR binding.
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===HUMAN ENTERIC ADENOVIRUS SEROTYPE 41 SHORT FIBER HEAD (PH8)===
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Crystal structure of enteric adenovirus serotype 41 short fiber head.,Seiradake E, Cusack S J Virol. 2005 Nov;79(22):14088-94. PMID:16254343<ref>PMID:16254343</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16254343}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bzv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16254343 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16254343}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2BZV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_41 Human adenovirus 41]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZV OCA].
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==Reference==
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Crystal structure of enteric adenovirus serotype 41 short fiber head., Seiradake E, Cusack S, J Virol. 2005 Nov;79(22):14088-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16254343 16254343]
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[[Category: Human adenovirus 41]]
[[Category: Human adenovirus 41]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cusack, S.]]
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[[Category: Cusack S]]
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[[Category: Seiradake, E.]]
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[[Category: Seiradake E]]
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[[Category: Ad41]]
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[[Category: Adenovirus]]
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[[Category: Fiber]]
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[[Category: Fiber protein]]
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[[Category: Receptor]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:06:37 2008''
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Current revision

Human Enteric Adenovirus Serotype 41 Short Fiber Head (pH8)

PDB ID 2bzv

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