This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2iqc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:04, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2iqc.png|left|200px]]
 
-
<!--
+
==Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex==
-
The line below this paragraph, containing "STRUCTURE_2iqc", creates the "Structure Box" on the page.
+
<StructureSection load='2iqc' size='340' side='right'caption='[[2iqc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2iqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQC FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-
{{STRUCTURE_2iqc| PDB=2iqc | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqc OCA], [https://pdbe.org/2iqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iqc RCSB], [https://www.ebi.ac.uk/pdbsum/2iqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iqc ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex===
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/FANCF_HUMAN FANCF_HUMAN] Defects in FANCF are the cause of Fanconi anemia complementation group F (FANCF) [MIM:[https://omim.org/entry/603467 603467]. A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.<ref>PMID:10615118</ref>
-
 
+
== Function ==
-
<!--
+
[https://www.uniprot.org/uniprot/FANCF_HUMAN FANCF_HUMAN] DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).
-
The line below this paragraph, {{ABSTRACT_PUBMED_17082180}}, adds the Publication Abstract to the page
+
== References ==
-
(as it appears on PubMed at http://www.pubmed.gov), where 17082180 is the PubMed ID number.
+
<references/>
-
-->
+
__TOC__
-
{{ABSTRACT_PUBMED_17082180}}
+
</StructureSection>
-
 
+
-
==Disease==
+
-
Known disease associated with this structure: Fanconi anemia, complementation group F OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603467 603467]]
+
-
 
+
-
==About this Structure==
+
-
2IQC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQC OCA].
+
-
 
+
-
==Reference==
+
-
Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex., Kowal P, Gurtan AM, Stuckert P, D'Andrea AD, Ellenberger T, J Biol Chem. 2007 Jan 19;282(3):2047-55. Epub 2006 Nov 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17082180 17082180]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Andrea, A D.]]
+
[[Category: D'Andrea A]]
-
[[Category: Ellenberger, T E.]]
+
[[Category: Ellenberger TE]]
-
[[Category: Gurtan, A M.]]
+
[[Category: Gurtan AM]]
-
[[Category: Kowal, P.]]
+
[[Category: Kowal P]]
-
[[Category: Lehmann, C.]]
+
[[Category: Lehmann C]]
-
[[Category: Stuckert, P.]]
+
[[Category: Stuckert P]]
-
[[Category: Complex subunit]]
+
-
[[Category: Dna-damage]]
+
-
[[Category: Fanconi]]
+
-
[[Category: Heat-like repeat]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:10:53 2008''
+

Current revision

Crystal structure of Human FancF Protein that Functions in the Assembly of a DNA Damage Signaling Complex

PDB ID 2iqc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2iqc"
Personal tools