2gj0

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{{Seed}}
 
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[[Image:2gj0.png|left|200px]]
 
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==Cycloviolacin O14==
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The line below this paragraph, containing "STRUCTURE_2gj0", creates the "Structure Box" on the page.
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<StructureSection load='2gj0' size='340' side='right'caption='[[2gj0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Viola_odorata Viola odorata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJ0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gj0 OCA], [https://pdbe.org/2gj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2gj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gj0 ProSAT]</span></td></tr>
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{{STRUCTURE_2gj0| PDB=2gj0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYO14_VIOOD CYO14_VIOOD]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyclotides are a fascinating family of plant-derived peptides characterized by their head-to-tail cyclized backbone and knotted arrangement of three disulfide bonds. This conserved structural architecture, termed the CCK (cyclic cystine knot), is responsible for their exceptional resistance to thermal, chemical and enzymatic degradation. Cyclotides have a variety of biological activities, but their insecticidal activities suggest that their primary function is in plant defence. In the present study, we determined the cyclotide content of the sweet violet Viola odorata, a member of the Violaceae family. We identified 30 cyclotides from the aerial parts and roots of this plant, 13 of which are novel sequences. The new sequences provide information about the natural diversity of cyclotides and the role of particular residues in defining structure and function. As many of the biological activities of cyclotides appear to be associated with membrane interactions, we used haemolytic activity as a marker of bioactivity for a selection of the new cyclotides. The new cyclotides were tested for their ability to resist proteolysis by a range of enzymes and, in common with other cyclotides, were completely resistant to trypsin, pepsin and thermolysin. The results show that while biological activity varies with the sequence, the proteolytic stability of the framework does not, and appears to be an inherent feature of the cyclotide framework. The structure of one of the new cyclotides, cycloviolacin O14, was determined and shown to contain the CCK motif. This study confirms that cyclotides may be regarded as a natural combinatorial template that displays a variety of peptide epitopes most likely targeted to a range of plant pests and pathogens.
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===Cycloviolacin O14===
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A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.,Ireland DC, Colgrave ML, Craik DJ Biochem J. 2006 Nov 15;400(1):1-12. PMID:16872274<ref>PMID:16872274</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16872274}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2gj0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16872274 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16872274}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2GJ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viola_odorata Viola odorata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJ0 OCA].
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==Reference==
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A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability., Ireland DC, Colgrave ML, Craik DJ, Biochem J. 2006 Nov 15;400(1):1-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16872274 16872274]
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[[Category: Single protein]]
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[[Category: Viola odorata]]
[[Category: Viola odorata]]
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[[Category: Colgrave, M L.]]
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[[Category: Colgrave ML]]
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[[Category: Craik, D J.]]
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[[Category: Craik DJ]]
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[[Category: Ireland, D C.]]
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[[Category: Ireland DC]]
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[[Category: Cyclotide]]
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[[Category: Plant protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:14:45 2008''
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Current revision

Cycloviolacin O14

PDB ID 2gj0

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