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1pum

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{{Seed}}
 
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[[Image:1pum.png|left|200px]]
 
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==Mistletoe lectin I in complex with galactose==
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The line below this paragraph, containing "STRUCTURE_1pum", creates the "Structure Box" on the page.
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<StructureSection load='1pum' size='340' side='right'caption='[[1pum]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pum]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PUM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1pum| PDB=1pum | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pum OCA], [https://pdbe.org/1pum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pum RCSB], [https://www.ebi.ac.uk/pdbsum/1pum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pum ProSAT]</span></td></tr>
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</table>
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===Mistletoe lectin I in complex with galactose===
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== Function ==
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[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16508080}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16508080 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/1pum_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16508080}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PUM OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pum ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Mistletoe lectin I in complex with galactose and lactose reveals distinct sugar-binding properties., Mikeska R, Wacker R, Arni R, Singh TP, Mikhailov A, Gabdoulkhakov A, Voelter W, Betzel C, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt, 1):17-25. Epub 2004 Dec 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16508080 16508080]
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<references/>
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[[Category: Betzel, C.]]
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__TOC__
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[[Category: Konareva, N.]]
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</StructureSection>
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[[Category: Krauspenhaar, R.]]
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[[Category: Large Structures]]
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[[Category: Mikhailov, A.]]
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[[Category: Viscum album]]
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[[Category: Stoeva, S.]]
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[[Category: Betzel C]]
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[[Category: Voelter, W.]]
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[[Category: Konareva N]]
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[[Category: Protein-sugar complex]]
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[[Category: Krauspenhaar R]]
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[[Category: Mikhailov A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:21:37 2008''
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[[Category: Stoeva S]]
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[[Category: Voelter W]]

Current revision

Mistletoe lectin I in complex with galactose

PDB ID 1pum

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