1nw3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:00, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1nw3.png|left|200px]]
 
-
<!--
+
==Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase==
-
The line below this paragraph, containing "STRUCTURE_1nw3", creates the "Structure Box" on the page.
+
<StructureSection load='1nw3' size='340' side='right'caption='[[1nw3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1nw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NW3 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1nw3| PDB=1nw3 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw3 OCA], [https://pdbe.org/1nw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw3 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nw3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nw3 ConSurf].
 +
<div style="clear:both"></div>
-
===Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase===
+
==See Also==
-
 
+
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12628190}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 12628190 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_12628190}}
+
-
 
+
-
==About this Structure==
+
-
1NW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW3 OCA].
+
-
 
+
-
==Reference==
+
-
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase., Min J, Feng Q, Li Z, Zhang Y, Xu RM, Cell. 2003 Mar 7;112(5):711-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12628190 12628190]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Feng, Q.]]
+
[[Category: Feng Q]]
-
[[Category: Li, Z H.]]
+
[[Category: Li ZH]]
-
[[Category: Min, J R.]]
+
[[Category: Min JR]]
-
[[Category: Xu, R M.]]
+
[[Category: Xu RM]]
-
[[Category: Zhang, Y.]]
+
[[Category: Zhang Y]]
-
[[Category: Hdot1]]
+
-
[[Category: Histone lysine methyltransferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:24:14 2008''
+

Current revision

Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

PDB ID 1nw3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nw3"
Personal tools