3c5x

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{{Seed}}
 
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[[Image:3c5x.png|left|200px]]
 
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==Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH==
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The line below this paragraph, containing "STRUCTURE_3c5x", creates the "Structure Box" on the page.
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<StructureSection load='3c5x' size='340' side='right'caption='[[3c5x]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Dengue_virus_2_Thailand/16681/84 Dengue virus 2 Thailand/16681/84]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SHD:ALPHA-D-ALTROPYRANOSE'>SHD</scene></td></tr>
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{{STRUCTURE_3c5x| PDB=3c5x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5x OCA], [https://pdbe.org/3c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5x RCSB], [https://www.ebi.ac.uk/pdbsum/3c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6H1E5_9FLAV Q6H1E5_9FLAV]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the proteolytic cleavage of the precursor membrane protein (prM), turning inert virus into infectious particles. We have determined the 2.2 angstrom resolution crystal structure of a recombinant protein in which the dengue virus prM is linked to the envelope glycoprotein E. The structure represents the prM-E heterodimer and fits well into the cryo-electron microscopy density of immature virus at neutral pH. The pr peptide beta-barrel structure covers the fusion loop in E, preventing fusion with host cell membranes. The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host.
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===Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH===
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The flavivirus precursor membrane-envelope protein complex: structure and maturation.,Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG Science. 2008 Mar 28;319(5871):1830-4. PMID:18369147<ref>PMID:18369147</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3c5x" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18369147 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18369147}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3C5X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5X OCA].
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==Reference==
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The flavivirus precursor membrane-envelope protein complex: structure and maturation., Li L, Lok SM, Yu IM, Zhang Y, Kuhn RJ, Chen J, Rossmann MG, Science. 2008 Mar 28;319(5871):1830-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18369147 18369147]
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
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[[Category: Protein complex]]
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[[Category: Dengue virus 2 Thailand/16681/84]]
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[[Category: Li, L.]]
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[[Category: Large Structures]]
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[[Category: Beta barrel]]
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[[Category: Li L]]
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[[Category: Helicase]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide-binding]]
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[[Category: Prm-e protein complex]]
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[[Category: Rna replication]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:25:47 2008''
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Current revision

Crystal structure of the precursor membrane protein- envelope protein heterodimer from the dengue 2 virus at low pH

PDB ID 3c5x

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