1oyi

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{{Seed}}
 
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[[Image:1oyi.png|left|200px]]
 
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==Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L==
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The line below this paragraph, containing "STRUCTURE_1oyi", creates the "Structure Box" on the page.
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<StructureSection load='1oyi' size='340' side='right'caption='[[1oyi]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OYI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oyi OCA], [https://pdbe.org/1oyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oyi RCSB], [https://www.ebi.ac.uk/pdbsum/1oyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oyi ProSAT]</span></td></tr>
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{{STRUCTURE_1oyi| PDB=1oyi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q86638_9POXV Q86638_9POXV]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/1oyi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oyi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The N-terminal domain of the vaccinia virus protein E3L (Z alpha(E3L)) is essential for full viral pathogenicity in mice. It has sequence similarity to the high-affinity human Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). Here, we report the solution structure of Z alpha(E3L) and the chemical shift map of its interaction surface with Z-DNA. The global structure and the Z-DNA interaction surface of Z alpha(E3L) are very similar to the high-affinity Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). However, the key Z-DNA contacting residue Y48 of Z alpha(E3L) adopts a different side chain conformation in unbound Z alpha(E3L), which requires rearrangement for binding to Z-DNA. This difference suggests a molecular basis for the significantly lower in vitro affinity of Z alpha(E3L) to Z-DNA compared with its homologues.
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===Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L===
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The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro.,Kahmann JD, Wecking DA, Putter V, Lowenhaupt K, Kim YG, Schmieder P, Oschkinat H, Rich A, Schade M Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2712-7. Epub 2004 Feb 23. PMID:14981270<ref>PMID:14981270</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14981270}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1oyi" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14981270 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14981270}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1OYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYI OCA].
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==Reference==
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The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro., Kahmann JD, Wecking DA, Putter V, Lowenhaupt K, Kim YG, Schmieder P, Oschkinat H, Rich A, Schade M, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2712-7. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981270 14981270]
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[[Category: Single protein]]
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[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Kahmann, J D.]]
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[[Category: Kahmann JD]]
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[[Category: Kim, Y G.]]
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[[Category: Kim Y-G]]
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[[Category: Lowenhaupt, K.]]
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[[Category: Lowenhaupt K]]
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[[Category: Oschkinat, H.]]
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[[Category: Oschkinat H]]
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[[Category: Putter, V.]]
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[[Category: Putter V]]
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[[Category: Rich, A.]]
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[[Category: Rich A]]
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[[Category: Schade, M.]]
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[[Category: Schade M]]
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[[Category: Schmieder, P.]]
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[[Category: Schmieder P]]
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[[Category: Wecking, D A.]]
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[[Category: Wecking DA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:27:07 2008''
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Current revision

Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L

PDB ID 1oyi

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