2fbn

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{{Seed}}
 
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[[Image:2fbn.png|left|200px]]
 
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==Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain==
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The line below this paragraph, containing "STRUCTURE_2fbn", creates the "Structure Box" on the page.
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<StructureSection load='2fbn' size='340' side='right'caption='[[2fbn]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fbn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FBN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbn OCA], [https://pdbe.org/2fbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fbn RCSB], [https://www.ebi.ac.uk/pdbsum/2fbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fbn ProSAT]</span></td></tr>
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{{STRUCTURE_2fbn| PDB=2fbn | SCENE= }}
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</table>
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== Function ==
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===Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain===
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[https://www.uniprot.org/uniprot/FKB35_PLAF7 FKB35_PLAF7] Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).<ref>PMID:15664653</ref> <ref>PMID:15850699</ref> <ref>PMID:17289400</ref> <ref>PMID:23974147</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17125854}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17125854 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fb/2fbn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17125854}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fbn ConSurf].
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2FBN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBN OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms., Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R, Mol Biochem Parasitol. 2007 Jan;151(1):100-10. Epub 2006 Nov 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17125854 17125854]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Single protein]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Dong A]]
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[[Category: Dong, A.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Hills T]]
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[[Category: Hills, T.]]
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[[Category: Hui R]]
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[[Category: Hui, R.]]
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[[Category: Koeieradzki I]]
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[[Category: Koeieradzki, I.]]
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[[Category: Lew J]]
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[[Category: Lew, J.]]
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[[Category: Melone M]]
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[[Category: Melone, M.]]
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[[Category: Sundararajan E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundararajan, E.]]
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[[Category: Wasney G]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Wasney, G.]]
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[[Category: Zhao Y]]
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[[Category: Weigelt, J.]]
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[[Category: Zhao, Y.]]
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[[Category: Pfl2275c]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Sulfur sad]]
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[[Category: Tpr-containing domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:31:36 2008''
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Current revision

Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain

PDB ID 2fbn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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