2ehb

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{{Seed}}
 
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[[Image:2ehb.png|left|200px]]
 
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==The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3==
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The line below this paragraph, containing "STRUCTURE_2ehb", creates the "Structure Box" on the page.
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<StructureSection load='2ehb' size='340' side='right'caption='[[2ehb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ehb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EHB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2ehb| PDB=2ehb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ehb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ehb OCA], [https://pdbe.org/2ehb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ehb RCSB], [https://www.ebi.ac.uk/pdbsum/2ehb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ehb ProSAT]</span></td></tr>
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</table>
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===The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3===
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== Function ==
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[https://www.uniprot.org/uniprot/CNBL4_ARATH CNBL4_ARATH] Acts as a calcium sensor involved in the regulatory pathway for the control of intracellular Na(+) and K(+) homeostasis and salt tolerance. Operates in synergy with CIPK24/SOS2 to activate the plasma membrane Na(+)/H(+) antiporter SOS1. May function as positive regulator of salt stress responses. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.<ref>PMID:11006339</ref> <ref>PMID:10725350</ref> <ref>PMID:12034882</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17499048 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/2ehb_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17499048}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2EHB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHB OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ehb ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3., Sanchez-Barrena MJ, Fujii H, Angulo I, Martinez-Ripoll M, Zhu JK, Albert A, Mol Cell. 2007 May 11;26(3):427-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17499048 17499048]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Sanchez-Barrena MJ]]
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[[Category: Sanchez-Barrena, M J.]]
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[[Category: Protein complex]]
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[[Category: Signalling protein/transferase complex]]
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[[Category: Sos2 fisl motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:45:43 2008''
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Current revision

The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3

PDB ID 2ehb

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