1nwr

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{{Seed}}
 
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[[Image:1nwr.png|left|200px]]
 
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==Crystal structure of human cartilage gp39 (HC-gp39)==
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The line below this paragraph, containing "STRUCTURE_1nwr", creates the "Structure Box" on the page.
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<StructureSection load='1nwr' size='340' side='right'caption='[[1nwr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nwr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1nwr| PDB=1nwr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwr OCA], [https://pdbe.org/1nwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwr RCSB], [https://www.ebi.ac.uk/pdbsum/1nwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwr ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
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== Function ==
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[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwr ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human cartilage gp39 (HC-gp39)===
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==See Also==
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*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12851408}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12851408 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12851408}}
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==About this Structure==
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1NWR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWR OCA].
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==Reference==
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Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39., Fusetti F, Pijning T, Kalk KH, Bos E, Dijkstra BW, J Biol Chem. 2003 Sep 26;278(39):37753-60. Epub 2003 Jul 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12851408 12851408]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bos, E.]]
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[[Category: Bos E]]
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[[Category: Dijkstra, B W.]]
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[[Category: Dijkstra BW]]
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[[Category: Fusetti, F.]]
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[[Category: Fusetti F]]
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[[Category: Kalk, K H.]]
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[[Category: Kalk KH]]
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[[Category: Pijning, T.]]
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[[Category: Pijning T]]
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[[Category: Chitin]]
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[[Category: Chitinase-like protein]]
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[[Category: N-acetylglucosamine]]
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[[Category: Rheumatoid arthritis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:51:57 2008''
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Current revision

Crystal structure of human cartilage gp39 (HC-gp39)

PDB ID 1nwr

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