3d3t

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{{Seed}}
 
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[[Image:3d3t.png|left|200px]]
 
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==Crystal Structure of HIV-1 CRF01_AE in complex with the substrate p1-p6==
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The line below this paragraph, containing "STRUCTURE_3d3t", creates the "Structure Box" on the page.
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<StructureSection load='3d3t' size='340' side='right'caption='[[3d3t]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d3t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(Z2/CDC-Z34_ISOLATE) Human immunodeficiency virus type 1 (Z2/CDC-Z34 ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D3T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d3t OCA], [https://pdbe.org/3d3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d3t RCSB], [https://www.ebi.ac.uk/pdbsum/3d3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d3t ProSAT]</span></td></tr>
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{{STRUCTURE_3d3t| PDB=3d3t | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q90VT5_9HIV1 Q90VT5_9HIV1] Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5'-UTR. At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shutt off translation (By similarity).[SAAS:SAAS012344_004_047815] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. Facilitates rearangement of nucleic acid secondary structure during retrotranscription of genomic RNA. This capability is referred to as nucleic acid chaperone activity (By similarity).[SAAS:SAAS012344_004_052592]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/3d3t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d3t ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of HIV-1 CRF01_AE in complex with the substrate p1-p6===
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==See Also==
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 18434392 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18434392}}
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==About this Structure==
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3D3T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D3T OCA].
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==Reference==
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Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6., Bandaranayake RM, Prabu-Jeyabalan M, Kakizawa J, Sugiura W, Schiffer CA, J Virol. 2008 Jul;82(13):6762-6. Epub 2008 Apr 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18434392 18434392]
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[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bandaranayake, R M.]]
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[[Category: Bandaranayake RM]]
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[[Category: Kakizawa, J.]]
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[[Category: Kakizawa J]]
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[[Category: Prabu-Jeyabalan, M.]]
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[[Category: Prabu-Jeyabalan M]]
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[[Category: Schiffer, C A.]]
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[[Category: Schiffer CA]]
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[[Category: Sugiura, W.]]
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[[Category: Sugiura W]]
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[[Category: Aid]]
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[[Category: Aspartyl protease]]
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[[Category: Crf01_ae]]
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[[Category: Hiv-1 protease]]
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[[Category: Hydrolase]]
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[[Category: Non-b clade]]
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[[Category: P1-p6 substrate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:59:14 2008''
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Current revision

Crystal Structure of HIV-1 CRF01_AE in complex with the substrate p1-p6

PDB ID 3d3t

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